دورية أكاديمية
Cell and Animal Models for SARS-CoV-2 Research
| العنوان: | Cell and Animal Models for SARS-CoV-2 Research |
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| المؤلفون: | Eloïne Bestion, Philippe Halfon, Soraya Mezouar, Jean-Louis Mège |
| المصدر: | Viruses, Vol 14, Iss 1507, p 1507 (2022) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2022 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | SARS-CoV-2, COVID-19, cell model, animal model, drug, Microbiology, QR1-502 |
| الوصف: | During the last two years following the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, development of potent antiviral drugs and vaccines has been a global health priority. In this context, the understanding of virus pathophysiology, the identification of associated therapeutic targets, and the screening of potential effective compounds have been indispensable advancements. It was therefore of primary importance to develop experimental models that recapitulate the aspects of the human disease in the best way possible. This article reviews the information concerning available SARS-CoV-2 preclinical models during that time, including cell-based approaches and animal models. We discuss their evolution, their advantages, and drawbacks, as well as their relevance to drug effectiveness evaluation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1999-4915 |
| العلاقة: | https://www.mdpi.com/1999-4915/14/7/1507Test; https://doaj.org/toc/1999-4915Test; https://doaj.org/article/8b40305c9b33477fa3813abc771631afTest |
| DOI: | 10.3390/v14071507 |
| الإتاحة: | https://doi.org/10.3390/v14071507Test https://doaj.org/article/8b40305c9b33477fa3813abc771631afTest |
| رقم الانضمام: | edsbas.39830BFA |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19994915 |
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| DOI: | 10.3390/v14071507 |