التفاصيل البيبلوغرافية
| العنوان: |
IRF4 rearrangement may predict favorable prognosis in children and young adults with primary head and neck large B‐cell lymphoma |
| المؤلفون: |
Jiang, Xiang‐Nan, Yu, Fang, Xue, Tian, Xia, Qing‐Xin, Bai, Qian‐Ming, Yu, Bao‐Hua, Shui, Ruo‐Hong, Zhou, Xiao‐Yan, Zhu, Xiong‐Zeng, Cao, Jun‐Ning, Hong, Xiao‐Nan, Li, Xiao‐Qiu |
| المساهمون: |
Chinese Society of Clinical Oncology, Science and Technology Commission of Shanghai Municipality |
| المصدر: |
Cancer Medicine ; volume 12, issue 9, page 10684-10693 ; ISSN 2045-7634 2045-7634 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2023 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Purpose Large B‐cell lymphoma with IRF4 rearrangement (LBCL, IRF4 +) has been recently recognized as a specific entity that is frequently associated with young age and favorable prognosis. However, whether the good outcome of the disease is due to IRF4 + or other factors remains obscure. We thus analyzed 100 young patients with primary head and neck LBCL to see the clinicopathologic correlates of IRF4 +. Methods The histopathology, immunophenotype, IRF4 status of the tumors, and clinical data were reviewed. Results Twenty‐one tumors were diagnosed as LBCL, IRF4 +, which were more frequently associated with a follicular growth pattern, medium‐sized blastoid cytology, germinal center B‐cell‐like, and CD5+ phenotype, compared with IRF4− ones. While most of the patients received chemotherapy with or without radiation, eight IRF4 + patients received mere surgical resection of the tumor and exhibited excellent outcome. IRF4 + cases featured a significantly higher complete remission rate, and better survivals compared with IRF4 − ones. Multivariate analysis confirmed IRF4 + correlates with a better survival. Conclusion Our work confirmed the unique clinicopathologic features of LBCL, IRF4 +, and disclosed for the first time the independent favorable prognostic impact of IRF4 +. These findings may further unravel the heterogeneity of LBCL occurring in youth, and aid in risk stratification and tailoring the therapeutic strategy. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1002/cam4.5828 |
| الإتاحة: |
https://doi.org/10.1002/cam4.5828Test |
| حقوق: |
http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.396C196E |
| قاعدة البيانات: |
BASE |
