دورية أكاديمية
The silencing of ets-4 mRNA relies on the functional cooperation between REGE-1/Regnase-1 and RLE-1/Roquin-1
| العنوان: | The silencing of ets-4 mRNA relies on the functional cooperation between REGE-1/Regnase-1 and RLE-1/Roquin-1 |
|---|---|
| المؤلفون: | Sobańska, Daria, Komur, Alicja A, Chabowska-Kita, Agnieszka, Gumna, Julita, Kumari, Pooja, Pachulska-Wieczorek, Katarzyna, Ciosk, Rafal |
| المساهمون: | Research Council of Norway, National Science Centre, Poland, The European Molecular Biology Organization, Institute of Bioorganic Chemistry, Polish Academy of Sciences |
| المصدر: | Nucleic Acids Research ; volume 50, issue 14, page 8226-8239 ; ISSN 0305-1048 1362-4962 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Genetics |
| الوصف: | Regnase-1 is an evolutionarily conserved endoribonuclease. It degrades diverse mRNAs important for many biological processes including immune homeostasis, development and cancer. There are two competing models of Regnase-1-mediated mRNA silencing. One model postulates that Regnase-1 works together with another RNA-binding protein, Roquin-1, which recruits Regnase-1 to specific mRNAs. The other model proposes that the two proteins function separately. Studying REGE-1, the Caenorhabditis elegans ortholog of Regnase-1, we have uncovered its functional relationship with RLE-1, the nematode counterpart of Roquin-1. While both proteins are essential for mRNA silencing, REGE-1 and RLE-1 appear to associate with target mRNA independently of each other. Thus, although the functional interdependence between REGE-1/Regnase-1 and RLE-1/Roquin-1 is conserved, the underlying mechanisms may display species-specific variation, providing a rare perspective on the evolution of this important post-transcriptional regulatory mechanism. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/nar/gkac609 |
| الإتاحة: | https://doi.org/10.1093/nar/gkac609Test https://academic.oup.com/nar/article-pdf/50/14/8226/45289700/gkac609.pdfTest |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.38FFCB6E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/nar/gkac609 |
|---|