دورية أكاديمية
Parkinson's Progression Markers Initiative: A Milestone-Based Strategy to Monitor Parkinson's Disease Progression
| العنوان: | Parkinson's Progression Markers Initiative: A Milestone-Based Strategy to Monitor Parkinson's Disease Progression |
|---|---|
| المؤلفون: | Brumm, Michael C., Siderowf, Andrew, Simuni, Tanya, Burghardt, Elliot, Choi, Seung Ho, Caspell-Garcia, Chelsea, Chahine, Lana M., Mollenhauer, Brit, Foroud, Tatiana, Galasko, Douglas, Merchant, Kalpana, Arnedo, Vanessa, Hutten, Samantha J., O’Grady, Alyssa N., Poston, Kathleen L., Tanner, Caroline M., Weintraub, Daniel, Kieburtz, Karl, Marek, Kenneth, Coffey, Christopher S., Parkinson’s Progression Markers Initiative |
| المساهمون: | Medical and Molecular Genetics, School of Medicine |
| المصدر: | PMC |
| بيانات النشر: | IOS Press |
| سنة النشر: | 2023 |
| المجموعة: | Indiana University - Purdue University Indianapolis: IUPUI Scholar Works |
| مصطلحات موضوعية: | Parkinson’s disease, Disease progression, Outcome measures, Clinical trials as topic |
| الوصف: | Background: Identifying a meaningful progression metric for Parkinson's disease (PD) that reflects heterogeneity remains a challenge. Objective: To assess the frequency and baseline predictors of progression to clinically relevant motor and non-motor PD milestones. Methods: Using data from the Parkinson's Progression Markers Initiative (PPMI) de novo PD cohort, we monitored 25 milestones across six domains ("walking and balance"; "motor complications"; "cognition"; "autonomic dysfunction"; "functional dependence"; "activities of daily living"). Milestones were intended to be severe enough to reflect meaningful disability. We assessed the proportion of participants reaching any milestone; evaluated which occurred most frequently; and conducted a time-to-first-event analysis exploring whether baseline characteristics were associated with progression. Results: Half of participants reached at least one milestone within five years. Milestones within the cognitive, functional dependence, and autonomic dysfunction domains were reached most often. Among participants who reached a milestone at an annual follow-up visit and remained active in the study, 82% continued to meet criteria for any milestone at one or more subsequent annual visits and 55% did so at the next annual visit. In multivariable analysis, baseline features predicting faster time to reaching a milestone included age (p < 0.0001), greater MDS-UPDRS total scores (p < 0.0001), higher GDS-15 depression scores (p = 0.0341), lower dopamine transporter binding (p = 0.0043), and lower CSF total α-synuclein levels (p = 0.0030). Symptomatic treatment was not significantly associated with reaching a milestone (p = 0.1639). Conclusion: Clinically relevant milestones occur frequently, even in early PD. Milestones were significantly associated with baseline clinical and biological markers, but not with symptomatic treatment. Further studies are necessary to validate these results, further assess the stability of milestones, and explore translating them into an ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | Journal of Parkinson's Disease; Brumm MC, Siderowf A, Simuni T, et al. Parkinson's Progression Markers Initiative: A Milestone-Based Strategy to Monitor Parkinson's Disease Progression. J Parkinsons Dis. 2023;13(6):899-916. doi:10.3233/JPD-223433; https://hdl.handle.net/1805/39508Test |
| الإتاحة: | https://doi.org/10.3233/JPD-223433Test https://hdl.handle.net/1805/39508Test |
| حقوق: | Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.38A86989 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |