دورية أكاديمية
International eDelphi Study to Reach Consensus on the Methotrexate Dosing Regimen in Patients with Psoriasis
| العنوان: | International eDelphi Study to Reach Consensus on the Methotrexate Dosing Regimen in Patients with Psoriasis |
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| المؤلفون: | Van Huizen, Astrid M., Menting, Stef P., Gyulai, Rolland, Iversen, Lars, van der Kraaij, Gayle E., Middelkamp-Hup, Maritza A., Warren, Richard B., Spuls, Phyllis I. |
| المصدر: | SPIN MTX Consensus Survey Study Group , Van Huizen , A M , Menting , S P , Gyulai , R , Iversen , L , van der Kraaij , G E , Middelkamp-Hup , M A , Warren , R B & Spuls , P I 2022 , ' International eDelphi Study to Reach Consensus on the Methotrexate Dosing Regimen in Patients with Psoriasis ' , JAMA Dermatology , vol. 158 , no. 5 , pp. 561-572 . https://doi.org/10.1001/jamadermatol.2022.0434Test |
| سنة النشر: | 2022 |
| المجموعة: | University of Groningen research database |
| الوصف: | Importance: A clear dosing regimen for methotrexate in psoriasis is lacking, and this might lead to a suboptimal treatment. Because methotrexate is affordable and globally available, a uniform dosing regimen could potentially optimize the treatment of patients with psoriasis worldwide. Objective: To reach international consensus among psoriasis experts on a uniform dosing regimen for treatment with methotrexate in adult and pediatric patients with psoriasis and identify potential future research topics. Design, Setting, and Participants: Between September 2020 and March 2021, a survey study with a modified eDelphi procedure that was developed and distributed by the Amsterdam University Medical Center and completed by 180 participants worldwide (55 [30.6%] resided in non-Western countries) was conducted in 3 rounds. The proposals on which no consensus was reached were discussed in a conference meeting (June 2021). Participants voted on 21 proposals with a 9-point scale (1-3 disagree, 4-6 neither agree nor disagree, 7-9 agree) and were recruited through the Skin Inflammation and Psoriasis International Network and European Academy of Dermatology and Venereology in June 2020. Apart from being a dermatologist/dermatology resident, there were no specific criteria for participation in the survey. The participants worked mainly at a university hospital (97 [53.9%]) and were experienced in treating patients with psoriasis with methotrexate (163 [91.6%] had more than 10 years of experience). Main Outcomes and Measures: In a survey with eDelphi procedure, we tried to reach consensus on 21 proposals. Consensus was defined as less than 15% voting disagree (1-3). For the consensus meeting, consensus was defined as less than 30% voting disagree. Results: Of 251 participants, 180 (71.7%) completed all 3 survey rounds, and 58 participants (23.1%) joined the conference meeting. Consensus was achieved on 11 proposals in round 1, 3 proposals in round 2, and 2 proposals in round 3. In the consensus meeting, consensus was achieved ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://research.rug.nl/en/publications/6c5b2c68-6857-4a2f-b4fa-a07def493826Test |
| DOI: | 10.1001/jamadermatol.2022.0434 |
| الإتاحة: | https://doi.org/10.1001/jamadermatol.2022.0434Test https://hdl.handle.net/11370/6c5b2c68-6857-4a2f-b4fa-a07def493826Test https://research.rug.nl/en/publications/6c5b2c68-6857-4a2f-b4fa-a07def493826Test https://pure.rug.nl/ws/files/217296753/jamadermatology_van_huizen_2022_cs_220001_1647280866.55573.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.388F07E0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1001/jamadermatol.2022.0434 |
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