التفاصيل البيبلوغرافية
| العنوان: |
11 C-Diprenorphine Binding in Huntington's Disease: A Comparison of Region of Interest Analysis with Statistical Parametric Mapping |
| المؤلفون: |
Weeks, Robert A., Cunningham, Vincent J., Piccini, Paola, Waters, Simon, Harding, Anita E., Brooks, David J. |
| المصدر: |
Journal of Cerebral Blood Flow & Metabolism ; volume 17, issue 9, page 943-949 ; ISSN 0271-678X 1559-7016 |
| بيانات النشر: |
SAGE Publications |
| سنة النشر: |
1997 |
| مصطلحات موضوعية: |
Cardiology and Cardiovascular Medicine, Neurology (clinical), Neurology |
| الوصف: |
We compare region of interest (ROI) analytical approaches with statistical parametric mapping (SPM) of 11 C-diprenorphine positron emission tomography findings in five patients with Huntington's disease (HD) and nine age-matched controls. The ROI were placed on caudate, putamen, and an occipital reference area. Ratios of striatal–occipital uptake from averaged static images centered at 60 minutes showed a mean 20% reduction in caudate ( P = 0.034) and 15% reduction in putamen ( P = 0.095) receptor binding in the HD patients. Dynamic data from caudate and putamen ROI, together with a plasma tracer input function, were analyzed using spectral analysis to give regional impulse response functions. Regional data at 60 minutes after impulse showed a mean 29% decrease in caudate ( P = 0.006) and 23% decrease in putamen ( P = 0.029) opioid binding in the HD cohort. Parametric images of tracer binding also were produced with spectral analysis on a voxel basis. The images of the unit impulse response function at 60 minutes showed a mean 31 % decrease in caudate ( P = 0.005) and a 26% decrease in putamen binding ( P = 0.011) in HD. The voxel-based parametric images were transformed into standard stereotactic space, and a between-group comparison (patient versus controls) was performed with SPM. This approach revealed symmetrical decreases in caudate (peak 40% decrease, z score = 4.38) and putamen opioid binding (peak 24% decrease, z score = 4.686) with additional nonhypothesized changes in cingulate, prefrontal, and thalamic areas. The significance and precision of changes measured with spectral analysis applied to dynamic data sets were superior to ROI-based ratio analysis on static images. The SPM replicated the striatal reductions in opioid binding in HD and detected additional nonpredicted changes. This study suggests that SPM is a valid alternative to conventional ROI analytical approaches for determining binding changes with positron emission tomography and may have advantages over region-based analyses in ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1097/00004647-199709000-00003 |
| الإتاحة: |
https://doi.org/10.1097/00004647-199709000-00003Test |
| حقوق: |
http://journals.sagepub.com/page/policies/text-and-data-mining-licenseTest |
| رقم الانضمام: |
edsbas.38626DB9 |
| قاعدة البيانات: |
BASE |
