التفاصيل البيبلوغرافية
| العنوان: |
A complex of α 6 integrin and E‐cadherin drives liver metastasis of colorectal cancer cells through hepatic angiopoietin‐like 6 |
| المؤلفون: |
Marchiò, Serena, Soster, Marco, Cardaci, Sabrina, Muratore, Andrea, Bartolini, Alice, Barone, Vanessa, Ribero, Dario, Monti, Maria, Bovino, Paola, Sun, Jessica, Giavazzi, Raffaella, Asioli, Sofia, Cassoni, Paola, Capussotti, Lorenzo, Pucci, Piero, Bugatti, Antonella, Rusnati, Marco, Pasqualini, Renata, Arap, Wadih, Bussolino, Federico |
| المصدر: |
EMBO Molecular Medicine ; volume 4, issue 11, page 1156-1175 ; ISSN 1757-4676 1757-4684 |
| بيانات النشر: |
Springer Science and Business Media LLC |
| سنة النشر: |
2012 |
| مصطلحات موضوعية: |
Molecular Medicine |
| الوصف: |
Homing of colorectal cancer (CRC) cells to the liver is a non‐random process driven by a crosstalk between tumour cells and components of the host tissue. Here we report the isolation of a liver metastasis‐specific peptide ligand (CGIYRLRSC) that binds a complex of E‐cadherin and α 6 integrin on the surface of CRC cells. We identify angiopoietin‐like 6 protein as a peptide‐mimicked natural ligand enriched in hepatic blood vessels of CRC patients. We demonstrate that an interaction between hepatic angiopoietin‐like 6 and tumoural α 6 integrin/E‐cadherin drives liver homing and colonization by CRC cells, and that CGIYRLRSC inhibits liver metastasis through interference with this ligand/receptor system. Our results indicate a mechanism for metastasis whereby a soluble factor accumulated in normal vessels functions as a specific ligand for circulating cancer cells. Consistently, we show that high amounts of coexpressed α 6 integrin and E‐cadherin in primary tumours represent a poor prognostic factor for patients with advanced CRC. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1002/emmm.201101164 |
| الإتاحة: |
https://doi.org/10.1002/emmm.201101164Test |
| حقوق: |
http://creativecommons.org/licenses/by/3.0Test/ |
| رقم الانضمام: |
edsbas.3860F02D |
| قاعدة البيانات: |
BASE |
