دورية أكاديمية
Intermittent fasting and health outcomes: an umbrella review of systematic reviews and meta-analyses of randomised controlled trials
| العنوان: | Intermittent fasting and health outcomes: an umbrella review of systematic reviews and meta-analyses of randomised controlled trials |
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| المؤلفون: | Sun, M.L., Yao, W., Wang, X.Y., Gao, S., Varady, K.A., Forslund, S.K., Zhang, M., Shi, Z.Y., Cao, F., Zou, B.J., Sun, M.H., Liu, K.X., Bao, Q., Xu, J., Qin, X., Xiao, Q., Wu, L., Zhao, Y.H., Zhang, D.Y., Wu, Q.J., Gong, T.T |
| بيانات النشر: | Elsevier / Lancet |
| سنة النشر: | 2024 |
| المجموعة: | Max-Delbrueck-Center for Molecular Medicine, Berlin: MDC Repository |
| مصطلحات موضوعية: | Function and Dysfunction of the Nervous System, Topic 3: Integrative Biomedicine |
| الوصف: | BACKGROUND: Benefits of Intermittent fasting (IF) on health-related outcomes have been found in a range of randomised controlled trials (RCTs). Our umbrella review aimed to systematically analyze and synthesize the available causal evidence on IF and its impact on specific health-related outcomes while evaluating its evidence quality. METHODS: We comprehensively searched the PubMed, Embase, Web of Science, and Cochrane databases (from inception up to 8 January 2024) to identify related systematic reviews and meta-analyses of RCTs investigating the association between IF and human health outcomes. We recalculated the effect sizes for each meta-analysis as mean difference (MD) or standardized mean difference (SMD) with corresponding 95% confidence intervals (CIs). Subgroup analyses were performed for populations based on three specific status: diabetes, overweight or obesity, and metabolic syndrome. The quality of systematic reviews was evaluated using A Measurement Tool to Assess Systematic Reviews (AMSTAR), and the certainty of evidence was assessed using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) system. This study is registered with PROSPERO (CRD42023382004). FINDINGS: A total of 351 associations from 23 meta-analyses with 34 health outcomes were included in the study. A wide range of outcomes were investigated, including anthropometric measures (n = 155), lipid profiles (n = 83), glycemic profiles (n = 57), circulatory system index (n = 41), appetite (n = 9), and others (n = 6). Twenty-one (91%) meta-analyses with 346 associations were rated as high confidence according to the AMSTAR criteria. The summary effects estimates were significant at p < 0.05 in 103 associations, of which 10 (10%) were supported by high certainty of evidence according to GRADE. Specifically, compared with non-intervention diet in adults with overweight or obesity, IF reduced waist circumference (WC) (MD = -1.02 cm; 95% CI: -1.99 to -0.06; p = 0.038), fat mass (MD = -0.72 kg; 95% CI: -1.32 to ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | http://edoc.mdc-berlin.de/24199/1/24199oa.pdfTest; http://edoc.mdc-berlin.de/24199/2/24199oa.pdfTest; Intermittent fasting and health outcomes: an umbrella review of systematic reviews and meta-analyses of randomised controlled trials. Sun, M.L. and Yao, W. and Wang, X.Y. and Gao, S. and Varady, K.A. and Forslund, S.K. and Zhang, M. and Shi, Z.Y. and Cao, F. and Zou, B.J. and Sun, M.H. and Liu, K.X. and Bao, Q. and Xu, J. and Qin, X. and Xiao, Q. and Wu, L. and Zhao, Y.H. and Zhang, D.Y. and Wu, Q.J. and Gong, T.T EClinicalMedicine 70 : 102519. April 2024 |
| DOI: | 10.1016/j.eclinm.2024.102519 |
| الإتاحة: | https://doi.org/10.1016/j.eclinm.2024.102519Test http://edoc.mdc-berlin.de/24199Test/ https://edoc.mdc-berlin.de/24199Test/ http://edoc.mdc-berlin.de/24199/1/24199oa.pdfTest http://edoc.mdc-berlin.de/24199/2/24199oa.pdfTest |
| حقوق: | cc_by_nc_nd_4 |
| رقم الانضمام: | edsbas.385F1D8B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.eclinm.2024.102519 |
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