دورية أكاديمية
Pharmacological Modulation of Temporal Discounting: A Systematic Review
| العنوان: | Pharmacological Modulation of Temporal Discounting: A Systematic Review |
|---|---|
| المؤلفون: | Luis Felipe Sarmiento, Jorge Alexander Ríos-Flórez, Hector Andres Paez-Ardila, Pêssi Socorro Lima de Sousa, Antonio Olivera-La Rosa, Anderson Manoel Herculano Oliveira da Silva, Amauri Gouveia |
| المصدر: | Healthcare; Volume 11; Issue 7; Pages: 1046 |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute MDPI MDPI AG |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | temporal discounting, decision-making, intertemporal decisions, drug administration, impulsivity, self-control, psy, socio |
| الوصف: | Temporal discounting is a phenomenon where a reward loses its value as a function of time (e.g., a reward is more valuable immediately than when it delays in time). This is a type of intertemporal decision-making that has an association with impulsivity and self-control. Many pathologies exhibit higher discounting rates, meaning they discount more the values of rewards, such as addictive behaviors, bipolar disorder, attention-deficit/hyperactivity disorders, social anxiety disorders, and major depressive disorder, among others; thus, many studies look for the mechanism and neuromodulators of these decisions. This systematic review aims to investigate the association between pharmacological administration and changes in temporal discounting. A search was conducted in PubMed, Scopus, Web of Science, Science Direct and Cochrane. We used the PICO strategy: healthy humans (P-Participants) that received a pharmacological administration (I-Intervention) and the absence of a pharmacological administration or placebo (C-Comparison) to analyze the relationship between the pharmacological administration and the temporal discounting (O-outcome). Nineteen studies fulfilled the inclusion criteria. The most important findings were the involvement of dopamine modulation in a U-shape for choosing the delayed outcome (metoclopradime, haloperidol, and amisulpride). Furthermore, administration of tolcapone and high doses of d-amphetamine produced a preference for the delayed option. There was a time-dependent hydrocortisone effect in the preference for the immediate reward. Thus, it can be concluded that dopamine is a crucial modulator for temporal discounting, especially the D2 receptor, and cortisol also has an important time-dependent role in this type of decision. One of the limitations of this systematic review is the heterogeneity of the drugs used to assess the effect of temporal discounting. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.3390/healthcare11071046Test |
| DOI: | 10.3390/healthcare11071046 |
| الإتاحة: | https://doi.org/10.3390/healthcare11071046Test |
| حقوق: | undefined |
| رقم الانضمام: | edsbas.385A49B1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/healthcare11071046 |
|---|