دورية أكاديمية
Decreased tryptophan and increased kynurenine levels in mastocytosis associated with digestive symptoms.
| العنوان: | Decreased tryptophan and increased kynurenine levels in mastocytosis associated with digestive symptoms. |
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| المؤلفون: | Georgin-Lavialle, Sophie, Launay, Jean-Marie, Côté, Francine, Soucié, Erinn, Soria, Angèle, Damaj, Gandhi, Moura, Daniela Silva, Canioni, Danielle, Hanssens, Katia, Chandesris, Marie-Olivia, Barète, Stéphane, Dubreuil, Patrice, Lortholary, Olivier, Hermine, Olivier, Sokol, Harry |
| المساهمون: | Université Pierre et Marie Curie - Paris 6 (UPMC), CHU Tenon AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre de référence des mastocytoses (CEREMAST), Hôpital Necker - Enfants Malades AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Laboratoire de Biochimie et Biologie Moléculaire, Hôpital Lariboisière-Fernand-Widal APHP, Laboratory of molecular mechanisms of hematologic disorders and therapeutic implications (ERL 8254 - Equipe Inserm U1163), Imagine - Institut des maladies génétiques (IMAGINE - U1163), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes (IPC), Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service d'Hématologie, CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Service d'anatomie pathologique CHU Necker, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Necker - Enfants Malades AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service d'Hématologie Adulte, Centre d'infectiologie Necker-Pasteur CHU Necker, Institut Pasteur Paris (IP)-Hôpital Necker - Enfants Malades AP-HP, CHU Saint-Antoine AP-HP, MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, SNFMI-Genzyme-maladies rares, Centre National de la Recherche Scientifique (CNRS), Assistance Publique Hopitaux de Paris (AP-HP) |
| المصدر: | ISSN: 0105-4538. |
| بيانات النشر: | HAL CCSD Wiley |
| سنة النشر: | 2016 |
| المجموعة: | AgroParisTech: HAL (Institut des sciences et industries du vivant et de l'environnement) |
| مصطلحات موضوعية: | tryptophan, mastocytosis, serotonin, IDO, kynurenine, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| الوصف: | International audience ; The main metabolism pathway of tryptophan is protein formation, but it can also be metabolized into serotonin and kynurenine. Indoleamine 2,3-dioxygenase (IDO) is the enzyme that catalyzes the degradation of tryptophan into kynurenine. Mastocytosis is a heterogeneous disease characterized by mast cell accumulation in various tissues with 57% of patients having gastrointestinal involvement. We studied tryptophan metabolism in mastocytosis patients displaying or not gastrointestinal features and healthy subjects (n = 26 in each group). Mastocytosis patients with digestive symptoms displayed significantly increased kynurenine level and IDO activity as compared to healthy controls and mastocytosis patients without digestive symptoms. This could be linked to mast cell-mediated digestive inflammation among patients with mastocytosis. This work is the first focusing on kynurenine pathway in a mast cell disease and could help to understand the pathogenesis of digestive features in mastocytosis as well as in other mast cell-mediated diseases. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/26841279; hal-01269697; https://hal.science/hal-01269697Test; https://hal.science/hal-01269697/documentTest; https://hal.science/hal-01269697/file/Georgin-Lavialle_2016_Decreased.pdfTest; PRODINRA: 350574; PUBMED: 26841279; WOS: 000369872100016 |
| DOI: | 10.1111/all.12802 |
| الإتاحة: | https://doi.org/10.1111/all.12802Test https://hal.science/hal-01269697Test https://hal.science/hal-01269697/documentTest https://hal.science/hal-01269697/file/Georgin-Lavialle_2016_Decreased.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.37EE410A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/all.12802 |
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