دورية أكاديمية
Effect of Intervention of Probiotics in Advance on Treg/Th17 in Premature Mice
| العنوان: | Effect of Intervention of Probiotics in Advance on Treg/Th17 in Premature Mice |
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| المؤلفون: | Mengmeng Liu, Juanjuan Mao, Shifa Zhang |
| المصدر: | BioMed Research International, Vol 2022 (2022) |
| بيانات النشر: | Hindawi Limited |
| سنة النشر: | 2022 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Medicine |
| الوصف: | To preliminarily understand the differentiation characteristics of regulatory T cells (Tregs) and Th17 at a different time in preterm mice, the impacts of probiotics on immune function progression, as well as the correlation of probiotics with Tregs and Th17. On embryonic day 18 of gestation, a mouse model of preterm birth was built using mifepristone (RU486). Following IPI of RU486, newborn mice were randomized to probiotics or NS gavage administration. Full-term newborn mice were given the same dose of NS gavage administration. Phenotypic analysis of peripheral immune cell frequency was performed using flow cytometry. Cytokine measurements were phenotyped by enzyme-linked immunosorbent assays. On the 14th and 21st days after birth, the highest and lowest expressions of Foxp3, the Treg transcription factor, were observed in full-term mice and premature mice by NS gavage administration, respectively, while the opposite trend was found in the Th17 transcription factor IL-17.IL-2, IL-6, and TGF-β rose with age but showed different trends among the three groups. IL-2 is the highest in full-term mice and the lowest in premature mice. IL-6 and TGF-β is the lowest in full-term mice and the highest in premature mice. Probiotics are beneficial to the development and maturation of the immune system, which may play a role in regulating the ratio of Treg/Th17. Probiotic preintervention can effectively promote the differentiation of Treg and inhibit the differentiation of Th17 in premature mice. Its mechanism of action may play a biological role by regulating cytokine (IL-2, IL-6, and TGF-β) secretions. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2314-6141 |
| العلاقة: | http://dx.doi.org/10.1155/2022/6131069Test; https://doaj.org/toc/2314-6141Test; https://doaj.org/article/7a1482d4170d4e099af98d324e7cc83bTest |
| DOI: | 10.1155/2022/6131069 |
| الإتاحة: | https://doi.org/10.1155/2022/6131069Test https://doaj.org/article/7a1482d4170d4e099af98d324e7cc83bTest |
| رقم الانضمام: | edsbas.37DBFEAA |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 23146141 |
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| DOI: | 10.1155/2022/6131069 |