دورية أكاديمية
Combinatorial Chemistry and Natural Products: Determination of the Biological Activity of OnBead, Double Cleavable Teicoplanin Aglycone (TD)
| العنوان: | Combinatorial Chemistry and Natural Products: Determination of the Biological Activity of OnBead, Double Cleavable Teicoplanin Aglycone (TD) |
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| المؤلفون: | Sizemore, Christine F., Seneci, Pierfausto, Kocis, Petr, Wertman, Kenneth F., Islam, Khalid |
| المصدر: | Protein & Peptide Letters ; volume 3, issue 4, page 253-260 ; ISSN 0929-8665 |
| بيانات النشر: | Bentham Science Publishers Ltd. |
| سنة النشر: | 1996 |
| مصطلحات موضوعية: | Biochemistry, General Medicine, Structural Biology |
| الوصف: | Teicoplanin aglycone (TD), a derivative of the naturally occurring antibiotic, was coupled to Tentagel resin beads using a releasable linker technique. The biological properties of the compound were examined in growth inhibition assays after cleavage of the linker under different pH conditions. The results show that combinatorial techniques on solid-phase can be used for large, complex molecules, and that the biological method described may be generally useful for high volume screening of large combinatorial chemical libraries. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.2174/092986650304220615154701 |
| الإتاحة: | https://doi.org/10.2174/092986650304220615154701Test https://www.eurekaselect.com/206048/articleTest |
| رقم الانضمام: | edsbas.378ADE8F |
| قاعدة البيانات: | BASE |
| DOI: | 10.2174/092986650304220615154701 |
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