دورية أكاديمية
Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases
| العنوان: | Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases |
|---|---|
| المؤلفون: | Pérez-Jiménez, Mercedes M., Monje-Moreno, José M., Brokate-Llanos, Ana María, Venegas-Calerón, Mónica, Sánchez-García, Alicia, Sansigre, Paula, Valladares, Amador, Esteban-García, Sara, Suárez-Pereira, Irene, Vitorica, Javier, Ríos, José Julián, Artal-Sanz, Marta, Carrión, Ángel M., Muñoz, Manuel J. |
| المساهمون: | Pérez-Jiménez,MM, Monje-Moreno,JM, Brokate-Llanos,AM, Sansigre,P, Valladares,A, Artal-Sanz,M, Muñoz,MJ Centro Andaluz de Biología del Desarrollo (CABD)—Universidad Pablo de Olavide (UPO), Departamento de Biología Molecular e Ingeniería Bioquímica, UPO/ CSIC/JA, Sevilla, Spain. Venegas-Calerón,M, Sánchez-García,A, Ríos,JJ Instituto de la Grasa (CSIC), Campus Universitario Pablo de Olavide (UPO), Sevilla, Spain. Esteban-García,S, Suárez-Pereira,I, Carrión,AM Departamento de Fisiología, Anatomía y Biología Celular, Universidad Pablo de Olavide (UPO), Sevilla, Spain. Vitorica,J Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universidad de Sevilla, Sevilla, Spain. Vitorica,J Instituto de Biomedicina de Sevilla (IBiS)-Hospital Universitario Virgen del Rocío/ CSIC/Universidad de Sevilla, Sevilla, Spain. Vitorica,J Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. Suárez-Pereira,I Europsychopharmacology and psychobiology research group, Universidad de Cadiz, CIBERSAM, INiBICA, Cadiz, Spain., This work was supported by the Junta de Andalucía Project P07-CVI-02697, “Fondo Europeo de Desarrollo Regional” (FEDER) and the “Consejería de Economía, Conocimiento, Empresas y Universidad, Junta de Andalucía” Project UPO-1266266 and the European Research Council ERC-2011-StG-281691. We also acknowledge the support from the Centro Andaluz de Biología del Desarrollo (CABD). |
| بيانات النشر: | Nature Publishing Group |
| سنة النشر: | 2021 |
| المجموعة: | Sistema Sanitario Público de Andalucía (SSPA): Repositorio |
| مصطلحات موضوعية: | Longevity, Alzheimer disease, Fertility, Aging, Mutation, Sensory neurons, Phenotype, Testosterone, Steroids, Sulfatases, Longevidad, Enfermedad de alzheimer, Fertilidad, Envejecimiento, Mutación, Células receptoras sensoriales, Fenotipo, Testosterona, Esteroides, Sulfatasas, Medical Subject Headings::Diseases::Nervous System Diseases::Neurodegenerative Diseases::Tauopathies::Alzheimer Disease, Medical Subject Headings::Organisms::Eukaryota::Animals, Medical Subject Headings::Organisms::Eukaryota::Animals::Invertebrates::Helminths::Nematoda::Secernentea::Rhabditida::Rhabditoidea::Caenorhabditis::Caenorhabditis elegans, Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Helminth Proteins::Caenorhabditis elegans Proteins, Medical Subject Headings::Diseases::Animal Diseases::Disease Models, Animal, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Epistasis, Genetic |
| الوصف: | Aging and fertility are two interconnected processes. From invertebrates to mammals, absence of the germline increases longevity. Here we show that loss of function of sul-2, the Caenorhabditis elegans steroid sulfatase (STS), raises the pool of sulfated steroid hormones, increases longevity and ameliorates protein aggregation diseases. This increased longevity requires factors involved in germline-mediated longevity (daf-16, daf-12, kri-1, tcer-1 and daf-36 genes) although sul-2 mutations do not affect fertility. Interestingly, sul-2 is only expressed in sensory neurons, suggesting a regulation of sulfated hormones state by environmental cues. Treatment with the specific STS inhibitor STX64, as well as with testosterone-derived sulfated hormones reproduces the longevity phenotype of sul-2 mutants. Remarkably, those treatments ameliorate protein aggregation diseases in C. elegans, and STX64 also Alzheimer's disease in a mammalian model. These results open the possibility of reallocating steroid sulfatase inhibitors or derivates for the treatment of aging and aging related diseases. ; Yes |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf; application/vnd.openxmlformats-officedocument.spreadsheetml.sheet; video/msvideo |
| اللغة: | English |
| تدمد: | 33397961 2041-1723 |
| العلاقة: | https://www.nature.com/articles/s41467-020-20269-yTest; Pérez-Jiménez MM, Monje-Moreno JM, Brokate-Llanos AM, Venegas-Calerón M, Sánchez-García A, Sansigre P, et al. Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases. Nat Commun. 2021 Jan 4;12(1):49; http://hdl.handle.net/10668/4311Test; PMC7782729 |
| DOI: | 10.1038/s41467-020-20269-y |
| الإتاحة: | https://doi.org/10.1038/s41467-020-20269-yTest http://hdl.handle.net/10668/4311Test |
| حقوق: | Atribución 4.0 Internacional ; http://creativecommons.org/licenses/by/4.0Test/ ; open access |
| رقم الانضمام: | edsbas.3747981E |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 33397961 20411723 |
|---|---|
| DOI: | 10.1038/s41467-020-20269-y |