دورية أكاديمية
Identifying phenotypes involved in susceptibility to Schistosoma mansoni infection in F1B6CBA mice
| العنوان: | Identifying phenotypes involved in susceptibility to Schistosoma mansoni infection in F1B6CBA mice |
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| المؤلفون: | Pérez del Villar, Luis, Vicente, Belén, Blanco-Gómez, Adrián, Castellanos-Martín, Andrés, Pérez-Losada, J., Muro, Antonio |
| المساهمون: | Fundación Ramón Areces, Junta de Castilla y León |
| بيانات النشر: | Walter de Gruyter Springer |
| سنة النشر: | 2014 |
| المجموعة: | Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| مصطلحات موضوعية: | F1B6CBA hybrid, Immunophenotypes, Experimental crosses, S. mansoni infection, Schistosomiasis susceptibility |
| الوصف: | This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. ; Schistosomiasis is a disease with a strong genetic component influenced by socioeconomic and ecological factors. Epidemiological studies have identified several genetic regions involved in the schistosomiasis susceptibility. However, it is not well known what physiological traits are predisposing to the disease. The study of experimental infections in inbred mouse strains with variable genetic susceptibility to the disease offers a good opportunity to tackle this question. F1B6CBA hybrid between the most divergent strains was infected in order to characterize the immunophenotypes that correlate with the susceptibility of schistosomiasis disease in mice. Complete blood counts and immunophenotype were determined at 0, 3, 6, and 9 weeks post infection. Nine weeks after cercariae exposure, animals were perfused and worm recovery was assessed. A large number of hepatic lesions, a reduction in the eosinophil and basophil count in the acute phase of infection and the decreased number of monocytes, neutrophils and B-lymphocytes are phenotypes associated with increased susceptibility to S. mansoni infection. ; The present study was supported by a grant from the Areces Foundation (2010–13) and funding of the Junta de Castilla y Leon (Orden EDU/330/2008). ; Peer Reviewed |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 1230-2821 |
| العلاقة: | Publisher's version; http://dx.doi.org/10.2478/s11686-014-0277-4Test; Sí; e-issn: 1896-1851; Acta Parasitologica 59(3): 529-539 (2014); http://hdl.handle.net/10261/134757Test; http://dx.doi.org/10.13039/100008054Test; http://dx.doi.org/10.13039/501100014180Test |
| DOI: | 10.2478/s11686-014-0277-4 |
| DOI: | 10.13039/100008054 |
| DOI: | 10.13039/501100014180 |
| الإتاحة: | https://doi.org/10.2478/s11686-014-0277-4Test https://doi.org/10.13039/100008054Test https://doi.org/10.13039/501100014180Test http://hdl.handle.net/10261/134757Test |
| حقوق: | open |
| رقم الانضمام: | edsbas.36BAF59F |
| قاعدة البيانات: | BASE |
| تدمد: | 12302821 |
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| DOI: | 10.2478/s11686-014-0277-4 |