التفاصيل البيبلوغرافية
| العنوان: |
Genome-wide detection and characterization of positive selection in human populations |
| المؤلفون: |
Lin, W, Sabeti, PC, Varilly, P, Fry, B, Lohmueller, J, Hostetter, E, Cotsapas, C, Xie, X, Byrne, EH, McCarroll, SA, Gaudet, R, Schaffner, SF, Lander, ES, Frazer, KA, Ballinger, DG, Cox, DR, Hinds, DA, Stuve, LL, Gibbs, RA, Belmont, JW, Boudreau, A, Hardenbol, P, Leal, SM, Pasternak, S, Wheeler, DA, Willis, TD, Yu, F, Yang, H, Zeng, C, Gao, Y, Hu, H, Hu, W, Li, C, Liu, S, Pan, H, Tang, X, Wang, J, Wang, W, Yu, J, Zhang, B, Zhang, Q, Zhao, H, Zhou, J, Gabriel, SB, Barry, R, Blumenstiel, B, Camargo, A, Defelice, M, Faggart, M, Goyette, M, Gupta, S, Moore, J, Nguyen, H, Onofrio, RC, Parkin, M, Roy, J, Stahl, E, Winchester, E, Ziaugra, L, Altshuler, D, Shen, Y, Yao, Z, Huang, W, Chu, X, He, Y, Jin, L, Liu, Y, Sun, W, Wang, H, Wang, Y, Xiong, X, Xu, L, Waye, MMY, Tsui, SKW, Xue, H, Wong, JTF, Galver, LM, Fan, JB, Gunderson, K, Murray, SS, Oliphant, AR, Chee, MS, Montpetit, A, Chagnon, F, Ferretti, V, Leboeuf, M, Olivier, JF, Phillips, MS, Roumy, S, Sallée, C, Verner, A, Hudson, TJ, Kwok, PY, Koboldt, DC, Miller, RD, Pawlikowska, L, TaillonMiller, P, Xiao, M, Mak, W, Nakamura, Y, Kawaguchi, T, Kitamoto, T, Morizono, T, Nagashima, A, Ohnishi, Y, Sekine, A, Tanaka, T, Tsunoda, T, Deloukas, P, Bird, CP, Delgado, M, Dermitzakis, ET, Gwilliam, R, Hunt, S, Morrison, J, Powell, D, Stranger, BE, Whittaker, P, Bentley, DR, Daly, MJ, De Bakker, PIW, Barrett, J, Chretien, YR, Maller, J, McCarroll, S, Patterson, N, Pe'Er, I, Price, A, Purcell, S, Richter, DJ, Saxena, R, Stein, LD, Krishnan, L, Smith, AV, TelloRuiz, MK, Thorisson, GA, Chakravarti, A, Chen, PE, Cutler, DJ, Kashuk, CS, Lin, S, Abecasis, GR, Guan, W, Li, Y, Munro, HM, Qin, ZS, Thomas, DJ, McVean, G, Auton, A, Bottolo, L, Cardin, N, Eyheramendy, S, Freeman, C, Marchini, J, Myers, S, Spencer, C, Stephens, M, Donnelly, P, Cardon, LR, Clarke, G, Evans, DM, Morris, AP, Weir, BS, Johnson, TA, Mullikin, JC, Sherry, ST, Feolo, M, Skol, A, Zhang, H, Matsuda, I, Fukushima, Y, MacEr, DR, Suda, E, Rotimi, CN, Adebamowo, CA, Ajayi, I, Aniagwu, T, Marshall, PA, Nkwodimmah, C, Leppert, MF, Dixon, M, Peiffer, A, Qiu, R, Kent, A, Kato, K, Niikawa, N, Adewole, IF, Knoppers, BM, Foster, MW, Clayton, EW, Watkin, J, Muzny, D, Nazareth, L, Sodergren, E, Weinstock, GM, Yakub, I, Birren, BW, Wilson, RK, Fulton, LL, Rogers, J, Burton, J, Carter, NP, Clee, CM, Griffiths, M, Jones, MC, McLay, K, Plumb, RW, Ross, MT, Sims, SK, Willey, DL, Chen, Z, Han, H, Kang, L, Godbout, M, Wallenburg, JC, L'Archevêque, P, Bellemare, G, Saeki, K, An, D, Fu, H, Li, Q, Wang, Z, Wang, R, Holden, AL, Brooks, LD, McEwen, JE, Guyer, MS, Wang, VO, Peterson, JL, Shi, M, Spiegel, J, Sung, LM, Zacharia, LF, Collins, FS, Kennedy, K, Jamieson, R, Stewart, J, Tsui, LC, You, QS, Tam, PKH, Sham, PC, Cai, D, Royal, CDM |
| بيانات النشر: |
//www.nature.com/nature
United Kingdom |
| سنة النشر: |
2007 |
| المجموعة: |
University of Hong Kong: HKU Scholars Hub |
| مصطلحات موضوعية: |
Europe, Regional Index: Eurasia |
| الوصف: |
With the advent of dense maps of human genetic variation, it is now possible to detect positive natural selection across the human genome. Here we report an analysis of over 3 million polymorphisms from the International HapMap Project Phase 2 (HapMap2). We used 'long-range haplotype' methods, which were developed to identify alleles segregating in a population that have undergone recent selection, and we also developed new methods that are based on cross-population comparisons to discover alleles that have swept to near-fixation within a population. The analysis reveals more than 300 strong candidate regions. Focusing on the strongest 22 regions, we develop a heuristic for scrutinizing these regions to identify candidate targets of selection. In a complementary analysis, we identify 26 non-synonymous, coding, single nucleotide polymorphisms showing regional evidence of positive selection. Examination of these candidates highlights three cases in which two genes in a common biological process have apparently undergone positive selection in the same population:LARGE and DMD, both related to infection by the Lassa virus, in West Africa;SLC24A5 and SLC45A2, both involved in skin pigmentation, in Europe; and EDAR and EDA2R, both involved in development of hair follicles, in Asia. ©2007 Nature Publishing Group. ; link_to_OA_fulltext |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| تدمد: |
0028-0836 |
| العلاقة: |
Nature; http://www.scopus.com/mlt/select.url?eid=2-s2.0-35349012592&selection=ref&src=s&origin=recordpageTest; Nature, 2007, v. 449 n. 7164, p. 913-918; 1780777; 918; 1094912; 139460; WOS:000250230600049; 7164; http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0028-0836&volume=449&issue=7164&spage=913&epage=918&date=2007&atitle=Genome-wide+detection+and+characterization+of+positive+selection+in+human+populationsTest+(Co-PI+of+Hong+Kong+Centre+which+responsible+2.5%+of+genome); PMC2687721; eid_2-s2.0-35349012592; 913; http://hdl.handle.net/10722/84522Test; 449 |
| DOI: |
10.1038/nature06250 |
| الإتاحة: |
https://doi.org/10.1038/nature06250Test
http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0028-0836&volume=449&issue=7164&spage=913&epage=918&date=2007&atitle=Genome-wide+detection+and+characterization+of+positive+selection+in+human+populationsTest+(Co-PI+of+Hong+Kong+Centre+which+responsible+2.5%+of+genome)
http://hdl.handle.net/10722/84522Test |
| رقم الانضمام: |
edsbas.36A9FF58 |
| قاعدة البيانات: |
BASE |
