دورية أكاديمية
Immune Monitoring Reveals Fusion Peptide Priming to Imprint Cross-Clade HIV-Neutralizing Responses with a Characteristic Early B Cell Signature
| العنوان: | Immune Monitoring Reveals Fusion Peptide Priming to Imprint Cross-Clade HIV-Neutralizing Responses with a Characteristic Early B Cell Signature |
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| المؤلفون: | Cheng, Cheng, Duan, Hongying, Xu, Kai, Chuang, Gwo-Yu, Corrigan, Angela R., Geng, Hui, O'Dell, Sijy, Ou, Li, Chambers, Michael, Changela, Anita, Chen, Xuejun, Foulds, Kathryn E., Sarfo, Edward K., Jafari, Alexander J., Hill, Kurt R., Kong, Rui, Liu, Kevin, Todd, John P., Tsybovsky, Yaroslav, Verardi, Raffaello, Wang, Shuishu, Wang, Yiran, Wu, Winston, Zhou, Tongqing, Arnold, Frank J., Doria-Rose, Nicole A., Koup, Richard A., McDermott, Adrian B., Scorpio, Diana G., Worobey, Michael, Shapiro, Lawrence, Mascola, John R., Kwong, Peter D. |
| المساهمون: | Univ Arizona, Dept Ecol & Evolutionary Biol |
| المصدر: | CELL REPORTS |
| بيانات النشر: | CELL PRESS |
| سنة النشر: | 2020 |
| المجموعة: | The University of Arizona: UA Campus Repository |
| الوصف: | The HIV fusion peptide (FP) is a promising vaccine target. FP-directed monoclonal antibodies from vaccinated macaques have been identified that neutralize up to similar to 60% of HIV strains; these vaccinations, however, have involved similar to 1 year with an extended neutralization-eclipse phase without measurable serum neutralization. Here, in 32 macaques, we test seven vaccination regimens, each comprising multiple immunizations of FP-carrier conjugates and HIV envelope (Env) trimers. Comparisons of vaccine regimens reveal FP-carrier conjugates to imprint cross-clade neutralizing responses and a cocktail of FP conjugate and Env trimer to elicit the earliest broad responses. We identify a signature, appearing as early as week 6 and involving the frequency of B cells recognizing both FP and Env trimer, predictive of vaccine-elicited breadth similar to 1 year later. Immune monitoring of B cells in response to vaccination can thus enable vaccine insights even in the absence of serum neutralization, here identifying FP imprinting, cocktail approach, and early signature as means to improve FP-directed vaccine responses. ; Open access journal ; This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2211-1247 |
| العلاقة: | Cheng, C., Duan, H., Xu, K., Chuang, G. Y., Corrigan, A. R., Geng, H., . & Kwong, P. D. (2020). Immune Monitoring Reveals Fusion Peptide Priming to Imprint Cross-Clade HIV-Neutralizing Responses with a Characteristic Early B Cell Signature. Cell Reports, 32(5), 107981.; http://hdl.handle.net/10150/657339Test; CELL REPORTS |
| DOI: | 10.1016/j.celrep.2020.107981 |
| الإتاحة: | https://doi.org/10.1016/j.celrep.2020.107981Test http://hdl.handle.net/10150/657339Test |
| حقوق: | Copyright © The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0Test/). ; https://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: | edsbas.369AE3E9 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 22111247 |
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| DOI: | 10.1016/j.celrep.2020.107981 |