دورية أكاديمية
Adult-to-adult living-donor liver transplantation: The experience of the Université catholique de Louvain.
| العنوان: | Adult-to-adult living-donor liver transplantation: The experience of the Université catholique de Louvain. |
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| المؤلفون: | Iesari, Samuele, Inostroza Núñez, Milton Eduardo, Rico Juri, Juan Manuel, Ciccarelli, Olga, Bonaccorsi-Riani, Eliano, Coubeau, Laurent, Laterre, Pierre-François, Goffette, Pierre, De Reyck, Chantal, Lengelé, Benoît, Gianello, Pierre, Lerut, Jan |
| المساهمون: | UCL - (SLuc) Service de chirurgie et transplantation abdominale, University of l'Aquila, Italy - Department of biotechnological and applied clinical sciences, Las Higueras Hospital, Talcahuano, Chile - Hepatobiliopancreatic Unit, Centro medico Imbanaco, Cali, Colombia - Cirugia de Trasplantes, UCL - (SLuc) Service de soins intensifs, UCL - (SLuc) Service de chirurgie plastique, UCL - (SLuc) Autre |
| المصدر: | Hepatobiliary & pancreatic diseases international : HBPD INT, Vol. 18, no.2, p. 132-142 (2019) |
| سنة النشر: | 2019 |
| المجموعة: | DIAL@USL-B (Université Saint-Louis, Bruxelles) |
| مصطلحات موضوعية: | Hepatocellular cancer, Liver transplantation, Living-donor, Secondary liver tumor, Small-for-size graft, Small-for-size syndrome |
| الوصف: | Liver transplantation is the treatment for end-stage liver diseases and well-selected malignancies. The allograft shortage may be alleviated with living donation. The initial UCLouvain experience of adult living-donor liver transplantation (LDLT) is presented. A retrospective analysis of 64 adult-to-adult LDLTs performed at our institution between 1998 and 2016 was conducted. The median age of 29 (45.3%) females and 35 (54.7%) males was 50.2 years (interquartile range, IQR 32.9-57.5). Twenty-two (34.4%) recipients had no portal hypertension. Three (4.7%) patients had a benign and 33 (51.6%) a malignant tumor [19 (29.7%) hepatocellular cancer, 11 (17.2%) secondary cancer and one (1.6%) each hemangioendothelioma, hepatoblastoma and embryonal liver sarcoma]. Median donor and recipient follow-ups were 93 months (IQR 41-159) and 39 months (22-91), respectively. Right and left hemi-livers were implanted in 39 (60.9%) and 25 (39.1%) cases, respectively. Median weights of right- and left-liver were 810 g (IQR 730-940) and 454 g (IQR 394-534), respectively. Graft-to-recipient weight ratios (GRWRs) were 1.17% (right, IQR 0.98%-1.4%) and 0.77% (left, 0.59%-0.95%). One- and five-year patient survivals were 85% and 71% (right) vs. 84% and 58% (left), respectively. One- and five-year graft survivals were 74% and 61% (right) vs. 76% and 53% (left), respectively. The patient and graft survival of right and left grafts and of very small (<0.6%), small (0.6%-0.79%) and large (≥0.8%) GRWR were similar. Survival of very small grafts was 86% and 86% at 3- and 12-month. No donor died while five (7.8%) developed a Clavien-Dindo complication IIIa, IIIb or IV. Recipient morbidity consisted mainly of biliary and vascular complications; three (4.7%) recipients developed a small-for-size syndrome according to the Kyushu criteria. Adult-to-adult LDLT is a demanding procedure that widens therapeutic possibilities of many hepatobiliary diseases. The donor procedure can be done safely with low morbidity. The recipient operation carries a ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1499-3872 |
| العلاقة: | boreal:218113; http://hdl.handle.net/2078.1/218113Test; info:pmid/30850341; urn:ISSN:1499-3872 |
| DOI: | 10.1016/j.hbpd.2019.02.007 |
| الإتاحة: | https://doi.org/10.1016/j.hbpd.2019.02.007Test http://hdl.handle.net/2078.1/218113Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.3638618D |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14993872 |
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| DOI: | 10.1016/j.hbpd.2019.02.007 |