دورية أكاديمية
The Molecular Subtype and Tumor Characteristics of Breast Cancer Metastases Significantly Influence Patient Post-Relapse Survival
| العنوان: | The Molecular Subtype and Tumor Characteristics of Breast Cancer Metastases Significantly Influence Patient Post-Relapse Survival |
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| المؤلفون: | Tobin, N. P., Harrell, J. C., Lövrot, J., Egyhazi Brage, S., Frostvik-Stolt, M., Fernö, M., Perou, C. M., Bergh, J., Hatschek, T., Lindström, L. S., for the TEX Trialists Group, Hatschek, Thomas, Fernö, Mårten, Lindström, Linda Sofie, Hedenfalk, Ingrid, Brandberg, Yvonne, Carstensen, John, Egyhazy, Suzanne, Stolt, Marianne Frostvik, Skoog, Lambert, Hellström, Mats, Maliniemi, Maarit, Svensson, Helene, Åström, Gunnar, Bergh, Jonas, Bjöhle, Judith, Lidbrink, Elisabet, Rotstein, Sam, Wallberg, Birgitta, Einbeigi, Zakaria, Carlsson, Per, Linderholm, Barbro, Walz, Thomas, Loman, Niklas, Malmström, Per, Söderberg, Martin, Malmberg, Martin, Carlsson, Lena, Lindh, Birgitta, Sundqvist, Marie, Malmberg, Lena |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2014 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Original article |
| الوصف: | <$O_ST_ABS>Background<$C_ST_ABS>We and others have recently shown that tumor characteristics are altered throughout tumor progression, which significantly influences patient survival. These findings emphasize the need for re-examination of tumor characteristics at relapse and have led to recommendations from ESMO and Swedish Breast Cancer group (SweBCG), amongst others. Here we aim to determine whether tumor characteristics and molecular subtypes in breast cancer metastases confer clinically relevant prognostic information for patients. <$O_ST_ABS>Patients and Methods<$C_ST_ABS>The translational aspect of the Swedish multicenter randomized trial called TEX included 111 patients with at least one biopsy from a morphologically confirmed loco-regional or distant breast cancer metastasis diagnosed from December 2002 until June 2007. All patients had detailed clinical information, complete follow-up and metastasis gene expression information (Affymetrix array GPL10379 |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | http://annonc.oxfordjournals.org/cgi/content/short/mdu498v1Test; http://dx.doi.org/10.1093/annonc/mdu498Test |
| DOI: | 10.1093/annonc/mdu498 |
| الإتاحة: | https://doi.org/10.1093/annonc/mdu498Test http://annonc.oxfordjournals.org/cgi/content/short/mdu498v1Test |
| حقوق: | Copyright (C) 2014, European Society for Medical Oncology |
| رقم الانضمام: | edsbas.362D0DEF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/annonc/mdu498 |
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