دورية أكاديمية
Stromal-like Wilms tumor cells induce human Natural Killer cell degranulation and display immunomodulatory properties towards NK cells
| العنوان: | Stromal-like Wilms tumor cells induce human Natural Killer cell degranulation and display immunomodulatory properties towards NK cells |
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| المؤلفون: | Cantoni C., Serra M., Parisi E., Azzarone B., Sementa A. R., Nasto L. A., Moretta L., Candiano G., Bottino C., Ghiggeri G. M., Spaggiari G. M. |
| المساهمون: | Cantoni, C., Serra, M., Parisi, E., Azzarone, B., Sementa, A. R., Nasto, L. A., Moretta, L., Candiano, G., Bottino, C., Ghiggeri, G. M., Spaggiari, G. M. |
| بيانات النشر: | Bellwether Publishing, Ltd. USA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA |
| سنة النشر: | 2021 |
| المجموعة: | Università degli Studi di Genova: CINECA IRIS |
| مصطلحات موضوعية: | COX-2, IDO, immunosuppression, mesenchymal stem cell, Natural Killer cell, PGE2, tumor microenvironment, Wilms tumor |
| الوصف: | The similarity of stromal-like Wilms tumor (str-WT) cells with mesenchymal stem cells (MSC), suggests their relevant role in the interplay with immune cells in the tumor microenvironment. We investigated the interaction between str-WT cells and NK cells. We observed that str-WT cells expressed some major ligands for activating and inhibitory NK cell receptors. Moreover, they expressed inhibitory checkpoint molecules involved in the negative regulation of anti-tumor immune response. The analysis of the interaction between str-WT cells and NK lymphocytes revealed that activated NK cells could efficiently degranulate upon interaction with str-WT cells. On the other hand, str-WT cells could exert potent inhibitory effects on cytokine-induced activation of NK cell proliferation and phenotype, which were mediated by the production of IDO and PGE2 inhibitory factors. Our data provide insight into the molecular interactions between str-WT cells and NK lymphocytes that may result in different outcomes possibly occurring in the WT microenvironment. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/33758675; info:eu-repo/semantics/altIdentifier/wos/WOS:000627791800001; volume:10; firstpage:1879530; lastpage:1879530-12; journal:ONCOIMMUNOLOGY; http://hdl.handle.net/11567/1064884Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85102210780 |
| DOI: | 10.1080/2162402X.2021.1879530 |
| الإتاحة: | https://doi.org/10.1080/2162402X.2021.1879530Test http://hdl.handle.net/11567/1064884Test |
| رقم الانضمام: | edsbas.35ED05DF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1080/2162402X.2021.1879530 |
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