دورية أكاديمية
The relationship between atherosclerosis and gut microbiome in patients with obstructive sleep apnoea
| العنوان: | The relationship between atherosclerosis and gut microbiome in patients with obstructive sleep apnoea |
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| المؤلفون: | Szabó, Helga, Piroska, Marton, Hernyes, Anita, Zoldi, Luca, Juhasz, János, Ligeti, Balazs, Makra, Nora, Szabo, Dora, Bikov, András, Kunos, László, Tárnoki, Ádám Domonkos, Tárnoki, Dávid László |
| بيانات النشر: | MDPI |
| سنة النشر: | 2022 |
| المجموعة: | MTAK: REAL (Library and Information Centre of the Hungarian Academy of Sciences / Magyar Tudományos Akadémia Könyvtár és Információs Központ) |
| مصطلحات موضوعية: | R1 Medicine (General) / orvostudomány általában |
| الوصف: | Background: Obstructive sleep apnoea (OSA) and gut dysbiosis are known risk factors for atherosclerosis. However, only very few studies have been focused on the relationship between OSA, atherosclerosis, and the intestinal microbiome, all in animal models. Methods: Twenty-two patients with OSA, 16 with and 6 without carotid atherosclerosis were involved in the study. After a diagnostic sleep examination, the intima media thickness (IMT) was measured and plaques were found using carotid ultrasound. Blood was also drawn for metabolic profile, and a stool sample was provided for 16S ribosomal RNA microbiome investigation. Results: An increased maximal common carotid artery (CCA) IMT was significantly associated with decreased phylum-level diversity. The level of Peptostreptococcaceae was significantly lower in atherosclerotic subjects. Some other candidate microbes appeared in the two groups at the genus level as well: Bilophila, Romboutsia, Slackia, and Veillonella in the non-atherosclerotic group; and Escherichia-Shigella, Prevotella, and Ruminococcaceae in the atherosclerotic group. Conclusions: This is the first pilot research to analyze the association between the gut microbiome and atherosclerosis in adult patients with OSA with and without carotid atherosclerosis. Dysbiosis and individual bacteria may contribute to the development of carotid atherosclerosis in patients with OSA. Further investigations are necessary to reveal a more precise background in a larger sample. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| العلاقة: | http://real.mtak.hu/175096/1/applsci-12-11484-v2.pdfTest; Szabó, Helga and Piroska, Marton and Hernyes, Anita and Zoldi, Luca and Juhasz, János and Ligeti, Balazs and Makra, Nora and Szabo, Dora and Bikov, András and Kunos, László and Tárnoki, Ádám Domonkos and Tárnoki, Dávid László (2022) The relationship between atherosclerosis and gut microbiome in patients with obstructive sleep apnoea. APPLIED SCIENCES, 12 (22). No-11484. ISSN 2076-3417 |
| DOI: | 10.3390/app122211484 |
| الإتاحة: | https://doi.org/10.3390/app122211484Test http://real.mtak.hu/175096Test/ http://real.mtak.hu/175096/1/applsci-12-11484-v2.pdfTest |
| حقوق: | cc_by |
| رقم الانضمام: | edsbas.34E05F22 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/app122211484 |
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