دورية أكاديمية
Microtubule-severing ATPase spastin in glioblastoma: increased expression in human glioblastoma cell lines and inverse roles in cell motility and proliferation
| العنوان: | Microtubule-severing ATPase spastin in glioblastoma: increased expression in human glioblastoma cell lines and inverse roles in cell motility and proliferation |
|---|---|
| المؤلفون: | Dráberová, E. (Eduarda), Vinopal, S. (Stanislav), Morfini, G., Liu, P. S., Sládková, V. (Vladimíra), Sulimenko, T. (Tetyana), Burns, M.R., Solowska, J., Kulandaivel, K., De Chadarévian, J.P., Legido, A., Mork, S.J., Janáček, J. (Jiří), Baas, P., Dráber, P. (Pavel), Katsetos, C.D. |
| سنة النشر: | 2011 |
| المجموعة: | The Czech Academy of Sciences: Publication Activity (ASEP) / Akademie věd ČR - Publikační činnost |
| مصطلحات موضوعية: | spastin, glioblastoma, cell motility |
| الوصف: | This research article is first report of the role of spastin in cell motility. The enzyme spastin is from microtubule-severing ATPases and regulates lenght of microtubules. Among strategies used for treating malignant tumors belongs disrupting the integrity of microtubules. The role of microtubules on invasivity has the higher propensity especially in glioblastoma cells from brain. To find the answer to question, if spastin and microtubules regulation somehow influence each other, spastin expression evaluation and testing of intracellular distribution was performed in human glioblastomas and astrocytes. It was found that spastin expression is increased in tumor cells. Surprisingly, functional experiments comparing the effects of spastin depletion on the motility and proliferation in glioblastomas have shown decreased motility and higher proliferation rate. The article proposes that spastin in glioblastomas might be linked to tumor cell invasion. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0022-3069 1554-6578 |
| العلاقة: | urn:pissn: 0022-3069; urn:eissn: 1554-6578; http://hdl.handle.net/11104/0200696Test |
| DOI: | 10.1097/NEN.0b013e31822c256d |
| الإتاحة: | https://doi.org/10.1097/NEN.0b013e31822c256dTest http://hdl.handle.net/11104/0200696Test |
| حقوق: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.34B97A42 |
| قاعدة البيانات: | BASE |
| تدمد: | 00223069 15546578 |
|---|---|
| DOI: | 10.1097/NEN.0b013e31822c256d |