التفاصيل البيبلوغرافية
| العنوان: |
Optical imaging correlates with magnetic resonance imaging breast density and reveals composition changes during neoadjuvant chemotherapy |
| المؤلفون: |
O'Sullivan, Thomas D, Leproux, Anaïs, Chen, Jeon-Hor, Bahri, Shadfar, Matlock, Alex, Roblyer, Darren, McLaren, Christine E, Chen, Wen-Pin, Cerussi, Albert E, Su, Min-Ying, Tromberg, Bruce J |
| بيانات النشر: |
BioMed Central Ltd. |
| سنة النشر: |
2013 |
| المجموعة: |
BioMed Central |
| الوصف: |
Introduction In addition to being a risk factor for breast cancer, breast density has been hypothesized to be a surrogate biomarker for predicting response to endocrine-based chemotherapies. The purpose of this study was to evaluate whether a noninvasive bedside scanner based on diffuse optical spectroscopic imaging (DOSI) provides quantitative metrics to measure and track changes in breast tissue composition and density. To access a broad range of densities in a limited patient population, we performed optical measurements on the contralateral normal breast of patients before and during neoadjuvant chemotherapy (NAC). In this work, DOSI parameters, including tissue hemoglobin, water, and lipid concentrations, were obtained and correlated with magnetic resonance imaging (MRI)-measured fibroglandular tissue density. We evaluated how DOSI could be used to assess breast density while gaining new insight into the impact of chemotherapy on breast tissue. Methods This was a retrospective study of 28 volunteers undergoing NAC treatment for breast cancer. Both 3.0-T MRI and broadband DOSI (650 to 1,000 nm) were obtained from the contralateral normal breast before and during NAC. Longitudinal DOSI measurements were used to calculate breast tissue concentrations of oxygenated and deoxygenated hemoglobin, water, and lipid. These values were compared with MRI-measured fibroglandular density before and during therapy. Results Water ( r = 0.843; P < 0.001), deoxyhemoglobin ( r = 0.785; P = 0.003), and lipid ( r = -0.707; P = 0.010) concentration measured with DOSI correlated strongly with MRI-measured density before therapy. Mean DOSI parameters differed significantly between pre- and postmenopausal subjects at baseline (water, P < 0.001; deoxyhemoglobin, P = 0.024; lipid, P = 0.006). During NAC treatment measured at about 90 days, significant reductions were observed in oxyhemoglobin for pre- (-20.0%; 95% confidence interval (CI), -32.7 to -7.4) and postmenopausal subjects (-20.1%; 95% CI, -31.4 to -8.8), and ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| العلاقة: |
http://breast-cancer-research.com/content/15/1/R14Test |
| الإتاحة: |
http://breast-cancer-research.com/content/15/1/R14Test |
| حقوق: |
Copyright 2013 O'Sullivan et al.; licensee BioMed Central Ltd. |
| رقم الانضمام: |
edsbas.3479FCCB |
| قاعدة البيانات: |
BASE |
