دورية أكاديمية
Anaemia, microcytosis and sirolimus-is iron the missing link?
| العنوان: | Anaemia, microcytosis and sirolimus-is iron the missing link? |
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| المؤلفون: | Sofroniadou, Sofia, Kassimatis, Theodoros, Goldsmith, David |
| المصدر: | Sofroniadou , S , Kassimatis , T & Goldsmith , D 2010 , ' Anaemia, microcytosis and sirolimus-is iron the missing link? ' , Nephrology, Dialysis, Transplantation , vol. 25 , no. 5 , pp. 1667-1675 . https://doi.org/10.1093/ndt/gfp674Test |
| سنة النشر: | 2010 |
| المجموعة: | King's College, London: Research Portal |
| مصطلحات موضوعية: | iron, microcytosis, post-transplantation anaemia, sirolimus, RENAL-TRANSPLANT RECIPIENTS, POSTTRANSPLANTATION ANEMIA, PRIMARY IMMUNOSUPPRESSION, ALLOGRAFT RECIPIENTS, ERYTHROPOIESIS, EXPERIENCE, EVEROLIMUS, DEFICIENCY, RAPAMYCIN, ADULT |
| الوصف: | Background. Sirolimus (SRL) has been implicated in the causation of post-transplantation anaemia (PTA). It also induces profound red blood cell (RBC) microcytosis, which is poorly understood. Methods. We conducted a retrospective study of SRL-induced anaemia and microcytosis [mean corpuscular volume (MCV) <80 fl] with specific reference to iron homeostasis in 93 renal transplant patients treated with SRL for at least 3 months. Results. While mean haemoglobin (Hb) and use of erythropoiesis-stimulating agents increased on SRL, RBC MCV underwent a significant decline throughout the whole study period of 24 months (P <0.001) with the percentage of microcytosis rising from 2.2% at the start of SRL therapy to 40.7% after 24 months of therapy. An association between dMCV (MCV change on SRL) and SRL levels was shown at 3, 6, 12 and 24 months post-SRL (P = 0.015, P = 0.037, P = 0.002 and P = 0.001, respectively). Intravenous (IV) iron administration was an independent predictor of dMCV at 12 and 24 months on SRL (P = 0.031 and P = 0.048, respectively). All patients who, after starting SRL and seeing a fall in MCV, then went on to receive IV iron therapy, showed a marked increase in MCV; this did not happen to patients given oral iron therapy. Conclusions. SRL is associated with mild anaemia, but marked RBC microcytosis-these phenomena are correlated with SRL levels and the use of IV iron. Functional iron deficiency and impaired gastrointestinal absorption of iron seem likely explanations. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/ndt/gfp674 |
| الإتاحة: | https://doi.org/10.1093/ndt/gfp674Test https://kclpure.kcl.ac.uk/portal/en/publications/8985dc2a-2a81-4ab8-b30c-610d7b2b4910Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.342CBD75 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/ndt/gfp674 |
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