دورية أكاديمية
Association between clinical complete response and pathological complete response after preoperative chemoradiation in patients with gastroesophageal cancer: analysis in a large cohort
| العنوان: | Association between clinical complete response and pathological complete response after preoperative chemoradiation in patients with gastroesophageal cancer: analysis in a large cohort |
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| المؤلفون: | Cheedella, N. K. S., Suzuki, A., Xiao, L., Hofstetter, W. L., Maru, D. M., Taketa, T., Sudo, K., Blum, M. A., Lin, S. H., Welch, J., Lee, J. H., Bhutani, M. S., Rice, D. C., Vaporciyan, A. A., Swisher, S. G., Ajani, J. A. |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2013 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | gastrointestinal tumors |
| الوصف: | Background Chemoradiation followed by surgery is the preferred treatment of localized gastroesophageal cancer (GEC). Surgery causes considerable life-altering consequences and achievement of clinical complete response (clinCR; defined as postchemoradiation [but presurgery] endoscopic biopsy negative for cancer and positron emission tomographic (PET) scan showing physiologic uptake) is an enticement to avoid/delay surgery. We examined the association between clinCR and pathologic complete response (pathCR). Patients and methods Two hundred eighty-four patients with GEC underwent chemoradiation and esophagectomy. The chi-square test, Fisher exact test, t -test, Kaplan–Meier method, and log-rank test were used. Results Of 284 patients, 218 (77%) achieved clinCR. However, only 67 (31%) of the 218 achieved pathCR. The sensitivity of clinCR for pathCR was 97.1% (67/69), but the specificity was low (29.8%; 64/215). Of the 66 patients who had less than a clinCR, only 2 (3%) had a pathCR. Thus, the rate of pathCR was significantly different in patients with clinCR than in those with less than a clinCR ( P < 0.001). Conclusions clinCR is not highly associated with pathCR; the specificity of clinCR for pathCR is too low to be used for clinical decision making on delaying/avoiding surgery. Surgery-eligible GEC patients should be encouraged to undergo surgery following chemoradiation despite achieving a clinCR. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | http://annonc.oxfordjournals.org/cgi/content/short/24/5/1262Test; http://dx.doi.org/10.1093/annonc/mds617Test |
| DOI: | 10.1093/annonc/mds617 |
| الإتاحة: | https://doi.org/10.1093/annonc/mds617Test http://annonc.oxfordjournals.org/cgi/content/short/24/5/1262Test |
| حقوق: | Copyright (C) 2013, European Society for Medical Oncology |
| رقم الانضمام: | edsbas.3418EAA7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/annonc/mds617 |
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