دورية أكاديمية
Corneal nerve fractal dimension: A novel corneal nerve metric for the diagnosis of diabetic sensorimotor polyneuropathy
| العنوان: | Corneal nerve fractal dimension: A novel corneal nerve metric for the diagnosis of diabetic sensorimotor polyneuropathy |
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| المؤلفون: | Chen, Xin, Graham, Jim, Petropoulos, Ioannis N., Ponirakis, Georgios, Asghar, Omar, Alam, Uazman, Marshall, Andrew, Ferdousi, Maryam, Azmi, Shazli, Efron, Nathan, Malik, Rayaz A. |
| المصدر: | Investigative Ophthalmology and Visual Science |
| بيانات النشر: | Association for Research in Vision and Ophthalmology Inc. |
| سنة النشر: | 2018 |
| المجموعة: | Queensland University of Technology: QUT ePrints |
| مصطلحات موضوعية: | Corneal confocal microscopy, Diabetic neuropathy, Image segmentation, Nerve fiber quantification |
| الوصف: | OBJECTIVE. Corneal confocal microscopy (CCM), an in vivo ophthalmic imaging modality, is a noninvasive and objective imaging biomarker for identifying small nerve fiber damage. We have evaluated the diagnostic performance of previously established CCM parameters to a novel automated measure of corneal nerve complexity called the corneal nerve fiber fractal dimension (ACNFrD). METHODS. A total of 176 subjects (84 controls and 92 patients with type 1 diabetes) with and without diabetic sensorimotor polyneuropathy (DSPN) underwent CCM. Fractal dimension analysis was performed on CCM images using purpose-built corneal nerve analysis software, and compared with previously established manual and automated corneal nerve fiber measurements. RESULTS. Manual and automated subbasal corneal nerve fiber density (CNFD) (P < 0.0001), length (CNFL) (P < 0.0001), branch density (CNBD) (P < 0.05), and ACNFrD (P < 0.0001) were significantly reduced in patients with DSPN compared to patients without DSPN. The areas under the receiver operating characteristic curves for identifying DSPN were comparable: 0.77 for automated CNFD, 0.74 for automated CNFL, 0.69 for automated CNBD, and 0.74 for automated ACNFrD. CONCLUSIONS. ACNFrD shows comparable diagnostic efficiency to identify diabetic patients with and without DSPN. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | https://eprints.qut.edu.au/230941/1/i1552_5783_59_2_1113.pdfTest; Chen, Xin, Graham, Jim, Petropoulos, Ioannis N., Ponirakis, Georgios, Asghar, Omar, Alam, Uazman, Marshall, Andrew, Ferdousi, Maryam, Azmi, Shazli, Efron, Nathan, & Malik, Rayaz A. (2018) Corneal nerve fractal dimension: A novel corneal nerve metric for the diagnosis of diabetic sensorimotor polyneuropathy. Investigative Ophthalmology and Visual Science, 59(2), pp. 1113-1118.; https://eprints.qut.edu.au/230941Test/; Institute of Health and Biomedical Innovation |
| الإتاحة: | https://doi.org/10.1167/iovs.17-23342Test https://eprints.qut.edu.au/230941Test/ |
| حقوق: | free_to_read ; http://creativecommons.org/licenses/by-nc-nd/4.0Test/ ; 2018 The Authors ; This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au |
| رقم الانضمام: | edsbas.340D707 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |