دورية أكاديمية
Influence of acute reduction of blood viscosity on endothelial function
| العنوان: | Influence of acute reduction of blood viscosity on endothelial function |
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| المؤلفون: | Gnasso A., Cacia M., Cutruzzola A., Minieri M., Carallo C., Cortese C., Irace C. |
| المساهمون: | Gnasso, A, Cacia, M, Cutruzzola, A, Minieri, M, Carallo, C, Cortese, C, Irace, C |
| بيانات النشر: | IOS Press |
| سنة النشر: | 2019 |
| المجموعة: | Universitá degli Studi di Roma "Tor Vergata": ART - Archivio Istituzionale della Ricerca |
| مصطلحات موضوعية: | blood donation, Blood viscosity, endothelial function, hematocrit, Adult, Endothelium, Vascular, Human, Male, Middle Aged, Settore BIO/12 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA |
| الوصف: | BACKGROUND: The relationship between blood viscosity (BV) and endothelial function is rather complex. An increase in BV causes an increase in blood flow resistance, with negative hemodynamic effects; on the other hand, a moderate increase in BV causes an increase in wall stress shear (WSS), and consequent beneficial effects. As a matter of fact, the effect of changes in BV on endothelial function is not yet clear. OBJECTIVES: Aim of the present study was to evaluate in-vivo the effects of the acute reduction in BV on endothelial function, in healthy male subjects. METHODS: Fourteen healthy male blood donors were studied before and 48 hours after blood donation. Blood and plasma viscosity were measured at 37C° with a cone-plate viscometer. Endothelial function was evaluated through flow mediated vasodilation (FMD). RESULTS: Blood viscosity was reduced after blood donation (BV225 (cP) 4.53±0.59 vs.4.18±0.31, p<0.05). FMD 50s after cuff deflation was unchanged: 6.23±3.84 vs. 6.62±4.81, p=NS. The vasodilation, however, lasted longer and the area under the curve of FMD was significantly increased: 8.74±8.77 vs.16.14±8.65, p<0.005. CONCLUSIONS: The present results demonstrate that the acute reduction of BV prolongs vasodilation, without affecting the amount of vasodilatation, possibly as adaptive reaction allowing more time for oxygen release. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/30909194; info:eu-repo/semantics/altIdentifier/wos/WOS:000486116500003; volume:72; issue:3; firstpage:239; lastpage:245; numberofpages:7; journal:CLINICAL HEMORHEOLOGY AND MICROCIRCULATION; http://hdl.handle.net/2108/227811Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85072235091; https://www.iospress.nl/journal/clinical-hemorheology-and-microcirculationTest/ |
| DOI: | 10.3233/CH-180446 |
| الإتاحة: | https://doi.org/10.3233/CH-180446Test http://hdl.handle.net/2108/227811Test https://www.iospress.nl/journal/clinical-hemorheology-and-microcirculationTest/ |
| حقوق: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.33EFDB09 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3233/CH-180446 |
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