التفاصيل البيبلوغرافية
| العنوان: |
Move and countermove: the integrated stress response in picorna- and coronavirus-infected cells |
| المؤلفون: |
Aloise, Chiara, Schipper, Jelle G, de Groot, Raoul J, van Kuppeveld, Frank Jm |
| المساهمون: |
Virologie |
| سنة النشر: |
2022 |
| مصطلحات موضوعية: |
Apoptosis, Degradation, Inhibition, Leader protein, Messenger-rna, Mouth-disease virus, Nucleotide exchange, Phosphorylation, Protein-kinase, Translation, Immunology and Allergy, Immunology |
| الوصف: |
Viruses, when entering their host cells, are met by a fierce intracellular immune defense. One prominent antiviral pathway is the integrated stress response (ISR). Upon activation of the ISR - typically though not exclusively upon detection of dsRNA - translation-initiation factor eukaryotic initiation factor 2 (eIF2) becomes phosphorylated to act as an inhibitor of guanine nucleotide-exchange factor eIF2B. Thus, with the production of ternary complex blocked, a global translational arrest ensues. Successful virus replication hinges on effective countermeasures. Here, we review ISR antagonists and antagonistic mechanisms employed by picorna- and coronaviruses. Special attention will be given to a recently discovered class of viral antagonists that inhibit the ISR by targeting eIF2B, thereby allowing unabated translation initiation even at exceedingly high levels of phosphorylated eIF2. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
0952-7915 |
| العلاقة: |
https://dspace.library.uu.nl/handle/1874/424343Test |
| الإتاحة: |
https://dspace.library.uu.nl/handle/1874/424343Test |
| حقوق: |
info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: |
edsbas.33C882B2 |
| قاعدة البيانات: |
BASE |
