دورية أكاديمية
A pendulum of induction between the epiblast and extra-embryonic endoderm supports post-implantation progression
| العنوان: | A pendulum of induction between the epiblast and extra-embryonic endoderm supports post-implantation progression |
|---|---|
| المؤلفون: | Vrij, Erik J, Scholte Op Reimer, Yvonne S, Roa Fuentes, Laury, Misteli Guerreiro, Isabel, Holzmann, Viktoria, Frias Aldeguer, Javier, Sestini, Giovanni, Koo, Bon-Kyoung, Kind, Jop, van Blitterswijk, Clemens A, Rivron, Nicolas C |
| المصدر: | Vrij , E J , Scholte Op Reimer , Y S , Roa Fuentes , L , Misteli Guerreiro , I , Holzmann , V , Frias Aldeguer , J , Sestini , G , Koo , B-K , Kind , J , van Blitterswijk , C A & Rivron , N C 2022 , ' A pendulum of induction between the epiblast and extra-embryonic endoderm supports post-implantation progression ' , Development (Cambridge) , vol. 149 , no. 20 . https://doi.org/10.1242/dev.192310Test |
| سنة النشر: | 2022 |
| المجموعة: | KNAW: Research Explorer (Koninklijke Nederlandse Akademie van Wetenschappen / Royal Netherlands Academy of Arts and Sciences) |
| مصطلحات موضوعية: | Animals, Blastocyst, Cell Differentiation, Cell Lineage/physiology, Embryo Implantation, Embryo, Mammalian, Endoderm, Germ Layers, Mice |
| الوصف: | Embryogenesis is supported by dynamic loops of cellular interactions. Here, we create a partial mouse embryo model to elucidate the principles of epiblast (Epi) and extra-embryonic endoderm co-development (XEn). We trigger naive mouse embryonic stem cells to form a blastocyst-stage niche of Epi-like cells and XEn-like cells (3D, hydrogel free and serum free). Once established, these two lineages autonomously progress in minimal medium to form an inner pro-amniotic-like cavity surrounded by polarized Epi-like cells covered with visceral endoderm (VE)-like cells. The progression occurs through reciprocal inductions by which the Epi supports the primitive endoderm (PrE) to produce a basal lamina that subsequently regulates Epi polarization and/or cavitation, which, in return, channels the transcriptomic progression to VE. This VE then contributes to Epi bifurcation into anterior- and posterior-like states. Similarly, boosting the formation of PrE-like cells within blastoids supports developmental progression. We argue that self-organization can arise from lineage bifurcation followed by a pendulum of induction that propagates over time. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://pure.knaw.nl/portal/en/publications/68d1c94d-eaa5-4672-8b61-3acbd4bcba2dTest |
| DOI: | 10.1242/dev.192310 |
| الإتاحة: | https://doi.org/10.1242/dev.192310Test https://doi.org/20.500.11755/68d1c94d-eaa5-4672-8b61-3acbd4bcba2dTest https://pure.knaw.nl/portal/en/publications/68d1c94d-eaa5-4672-8b61-3acbd4bcba2dTest https://hdl.handle.net/20.500.11755/68d1c94d-eaa5-4672-8b61-3acbd4bcba2dTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.33532EB7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1242/dev.192310 |
|---|