دورية أكاديمية
Imported falciparum malaria in adults: host- and parasite-related factors associated with severity. The French prospective multicenter PALUREA cohort study
| العنوان: | Imported falciparum malaria in adults: host- and parasite-related factors associated with severity. The French prospective multicenter PALUREA cohort study |
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| المؤلفون: | Bruneel, Fabrice, Tubach, Florence, Mira, Jean-Paul, Houzé, Sandrine, Gibot, Sébastien, Huisse, Marie-Geneviève, Megarbane, Bruno, Choquet, Christophe, Corne, Philippe, Peytel, Eric, Villers, Daniel, Camus, Christophe, Bouchaud, Olivier, Caumes, Eric, Girard, Pierre Marie, Simon, Fabrice, Kalloumeh, Antoine, Roy, Carine, Durand, Rémy, Le Bras, Jacques, Matheron, Sophie, Wolff, Michel |
| المساهمون: | Service de réanimation CH Versailles, Centre Hospitalier de Versailles André Mignot (CHV), Université Sorbonne Paris Cité (USPC), Département d’Epidémiologie et Recherche Clinique AP-HP Hôpital Bichat - Claude Bernard (CIC‑EC 1425), AP-HP - Hôpital Bichat - Claude Bernard Paris, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Epidémiologie Clinique et Evaluation Economique Appliquées aux Populations Vulnérables (ECEVE (U1123 / UMR_S_1123)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AP-HP Hôpital universitaire Robert-Debré Paris, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de médecine d'urgence CHU Cochin, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Parasitologie Mycologie AP-HP Hôpital Bichat - Claude Bernard, Service de Réanimation Médicale CHRU Nancy, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Service d'hématologie et immunologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard Paris, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Service de réanimation médicale et toxicologique AP-HP Hôpital Lariboisière, Hôpital Lariboisière-Fernand-Widal APHP, Service d’Accueil des Urgences AP-HP Hôpital Bichat - Claude Bernard, Département d'anesthésie-réanimation Montpellier, Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier)-Hôpital Gui de Chauliac CHU Montpellier, Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), Service d’Anesthésiologie et Réanimation H.I.A Laveran, Marseille, Hôpital d'instruction des armées Laveran Marseille, Service de Réanimation Médicale Polyvalente Hôtel Dieu, Nantes, Hôtel-Dieu de Nantes, Service des maladies infectieuses et réanimation médicale Rennes = Infectious Disease and Intensive Care Rennes, Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Ponchaillou, Service des maladies infectieuses et tropicales, Université Paris 13 (UP13)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne AP-HP, CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Saint-Antoine AP-HP, Service de Pathologie Infectieuse et Tropicale HIA Laveran, Marseille, Hôpital d'instruction des armées Laveran, Unité de Biochimie Clinique AP-HP Hôpital Bichat-Claude-Bernard, Laboratoire de Parasitologie-Mycologie CHU Avicenne, Hôpital Avicenne AP-HP, Unité de Soins Intensifs et de Maladies Infectieuses, This work was supported by a research grant from the French Ministry of Health (Programme Hospitalier de Recherche Clinique, PHRC—#AOR05007). The sponsor was the public organization Département de la Recherche Clinique et du Développement, Assistance Publique—Hôpitaux de Paris.The trial is registered on ClinicalTrials.gov (#NCT00372684)., The PALUREA Study Group |
| المصدر: | ISSN: 0342-4642. |
| بيانات النشر: | HAL CCSD Springer Verlag |
| سنة النشر: | 2016 |
| المجموعة: | Inserm: HAL (Institut national de la santé et de la recherche médicale) |
| مصطلحات موضوعية: | CRP, Albumin, ICU PATIENTS, Biomarkers, STREM-1, Malaria, PCT, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| الوصف: | The online version of this article (doi:10.1007/s00134-016-4356-x) contains supplementary material, which is available to authorized users. ; International audience ; PURPOSE: Prospective data on potential factors associated with severity of imported Plasmodium falciparum malaria are lacking. We evaluated whether several host- and parasite-related biomarkers may improve early severity evaluation.METHODS: Prospective multicenter observational study comparing uncomplicated and severe imported falciparum malaria in adults conducted in France in 52 units, from 2007 to 2010. Association of several host- and parasite-related biomarkers with severity of malaria was tested using univariate and multivariate analyses.RESULTS: Of 295 patients, 140 had uncomplicated malaria and 155 severe malaria (including very severe and less severe cases according to predefined criteria). Curative intravenous quinine treatment was used in 154/155 patients with severe malaria and atovaquone/proguanil in 74 % of patients with uncomplicated malaria. Hospital mortality was 5.2 % (8 patients), all in the severe malaria group. Among host-related biomarkers, CRP, procalcitonin, and sTREM-1 were significantly higher and albumin was significantly lower in severe versus uncomplicated malaria; only the last three biomarkers also differed significantly between the very and less severe malaria groups. Among parasite-related biomarkers, only plasma PfHRP2 was significantly higher in severe versus uncomplicated malaria and in very severe versus less severe malaria; parasitemia did not differ between very and less severe malaria. By multivariate analysis, only lower plasma albumin and higher sTREM-1 were associated with greater severity, with intermediate accuracies.CONCLUSIONS: During imported malaria, the most useful biomarkers associated with severity seem to be plasma albumin and sTREM-1; and among parasite-related parameters, PfHRP2 was more strongly associated with severity than parasitemia was. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/27169586; inserm-01524538; https://inserm.hal.science/inserm-01524538Test; https://inserm.hal.science/inserm-01524538/documentTest; https://inserm.hal.science/inserm-01524538/file/PALUREA%201%20Intensive%20Care%20Med%202016.pdfTest; https://inserm.hal.science/inserm-01524538/file/Supp%20PALUREA%201%20Fig%20Biomarkers%20%20ICM%202016.pdfTest; https://inserm.hal.science/inserm-01524538/file/Supp%20PALUREA%201%20ICM%202016.pdfTest; PUBMED: 27169586 |
| DOI: | 10.1007/s00134-016-4356-x |
| الإتاحة: | https://doi.org/10.1007/s00134-016-4356-xTest https://inserm.hal.science/inserm-01524538Test https://inserm.hal.science/inserm-01524538/documentTest https://inserm.hal.science/inserm-01524538/file/PALUREA%201%20Intensive%20Care%20Med%202016.pdfTest https://inserm.hal.science/inserm-01524538/file/Supp%20PALUREA%201%20Fig%20Biomarkers%20%20ICM%202016.pdfTest https://inserm.hal.science/inserm-01524538/file/Supp%20PALUREA%201%20ICM%202016.pdfTest |
| رقم الانضمام: | edsbas.332F196 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00134-016-4356-x |
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