دورية أكاديمية
Short-Course Radiotherapy Followed by Neoadjuvant Bevacizumab, Capecitabine, and Oxaliplatin and Subsequent Radical Treatment in Primary Stage IV Rectal Cancer:Long-Term Results of a Phase II Study
| العنوان: | Short-Course Radiotherapy Followed by Neoadjuvant Bevacizumab, Capecitabine, and Oxaliplatin and Subsequent Radical Treatment in Primary Stage IV Rectal Cancer:Long-Term Results of a Phase II Study |
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| المؤلفون: | Bisschop, C., van Dijk, T. H., Beukema, J. C., Jansen, R. L. H., Gelderblom, H., de Jong, K. P., Rutten, H. J. T., van de Velde, C. J. H., Wiggers, T., Havenga, K., Hospers, G. A. P. |
| المصدر: | Bisschop , C , van Dijk , T H , Beukema , J C , Jansen , R L H , Gelderblom , H , de Jong , K P , Rutten , H J T , van de Velde , C J H , Wiggers , T , Havenga , K & Hospers , G A P 2017 , ' Short-Course Radiotherapy Followed by Neoadjuvant Bevacizumab, Capecitabine, and Oxaliplatin and Subsequent Radical Treatment in Primary Stage IV Rectal Cancer : Long-Term Results of a Phase II Study ' , Annals of Surgical Oncology , vol. 24 , no. .... |
| سنة النشر: | 2017 |
| المجموعة: | University of Groningen research database |
| مصطلحات موضوعية: | COLORECTAL LIVER METASTASES, SYNCHRONOUS UNRESECTABLE METASTASES, PALLIATIVE RADIOTHERAPY, SURGERY, CHEMOTHERAPY, RESECTION, CHEMORADIOTHERAPY, MANAGEMENT, PROGNOSIS, OUTCOMES |
| الوصف: | Background. In a Dutch phase II trial conducted between 2006 and 2010, short-course radiotherapy followed by systemic therapy with capecitabine, oxaliplatin, and bevacizumab as neoadjuvant treatment and subsequent radical surgical treatment of primary tumor and metastatic sites was evaluated. In this study, we report the long-term results after a minimum follow-up of 6 years. Methods. Patients with histologically confirmed rectal adenocarcinoma with potentially resectable or ablatable metastases in liver or lungs were eligible. Follow-up data were collected for all patients enrolled in the trial. Overall and recurrence-free survival were calculated using the Kaplan-Meier method. Results. Follow-up data were available for all 50 patients. After a median follow-up time of 8.1 years (range 6.0-9.8), 16 patients (32.0%) were still alive and 14 (28%) were disease-free. The median overall survival was 3.8 years (range 0.5-9.4). From the 36 patients who received radical treatment, two (5.6%) had a local recurrence and 29 (80.6%) had a distant recurrence. Conclusions. Long-term survival can be achieved in patients with primary metastatic rectal cancer after neoadjuvant radio- and chemotherapy. Despite a high number of recurrences, 32% of patients were alive after a median follow-up time of 8.1 years. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://research.rug.nl/en/publications/5dc3c42c-a030-4038-8f92-ec0195fa4c92Test |
| DOI: | 10.1245/s10434-017-5897-0 |
| الإتاحة: | https://doi.org/10.1245/s10434-017-5897-0Test https://hdl.handle.net/11370/5dc3c42c-a030-4038-8f92-ec0195fa4c92Test https://research.rug.nl/en/publications/5dc3c42c-a030-4038-8f92-ec0195fa4c92Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.3300259A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1245/s10434-017-5897-0 |
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