دورية أكاديمية
Impact of weight loss on cancer-related proteins in serum:results from a cluster randomised-controlled trial of individuals with type 2 diabetes
| العنوان: | Impact of weight loss on cancer-related proteins in serum:results from a cluster randomised-controlled trial of individuals with type 2 diabetes |
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| المؤلفون: | Bull, Caroline J, Hazelwood, Emma, Legge, Danny N, Corbin, Laura J, Richardson, Tom G, Lee, Matthew, Yarmolinsky, James, Smith-Byrne, Karl, Hughes, David A, Johansson, Mattias, Peters, Ulrike, Berndt, Sonja I, Brenner, Hermann, Burnett-Hartman, Andrea, Cheng, Iona, Kweon, Sun-Seog, Le Marchand, Loic, Li, Li, Newcomb, Polly A, Pearlman, Rachel, McConnachie, Alex, Welsh, Paul, Taylor, Roy, Lean, Mike E. J., Sattar, Naveed, Murphy, Neil, Gunter, Marc, Timpson, Nicholas John, Vincent, Emma E |
| المصدر: | Bull , C J , Hazelwood , E , Legge , D N , Corbin , L J , Richardson , T G , Lee , M , Yarmolinsky , J , Smith-Byrne , K , Hughes , D A , Johansson , M , Peters , U , Berndt , S I , Brenner , H , Burnett-Hartman , A , Cheng , I , Kweon , S-S , Le Marchand , L , Li , L , Newcomb , P A , Pearlman , R , McConnachie , A , Welsh , P , Taylor , R .... |
| سنة النشر: | 2024 |
| المجموعة: | University of Bristol: Bristol Reserach |
| مصطلحات موضوعية: | /dk/atira/pure/core/keywords/icep, name=ICEP |
| الوصف: | Background: Type 2 diabetes is associated with higher risk of several cancer types. However, the biological intermediates driving this relationship are not fully understood. As novel interventions for treating and managing type 2 diabetes become increasingly available, whether they also disrupt the pathways leading to increased cancer risk is currently unknown. We investigated the effect of a type 2 diabetes intervention, in the form of intentional weight loss, on circulating proteins associated with cancer risk to gain insight into potential mechanisms linking type 2 diabetes and adiposity with cancer development. Methods: Fasting serum samples from participants with diabetes enrolled in the Diabetes Remission Clinical Trial (DiRECT) receiving the Counterweight-Plus weight-loss programme (intervention, N = 117, mean weight-loss 10kg, 46% diabetes remission) or best-practice care by guidelines (control, N = 143, mean weight-loss 1kg, 4% diabetes remission) were subject to proteomic analysis using the Olink Oncology-II platform (48% of participants were female; 52% male). To identify proteins which may be altered by the weight-loss intervention, the difference in protein levels between groups at baseline and 1 year was examined using linear regression. Mendelian randomization (MR) was performed to extend these results to evaluate cancer risk and elucidate possible biological mechanisms linking type 2 diabetes and cancer development. MR analyses were conducted using independent datasets, including large cancer meta-analyses, UK Biobank, and FinnGen, to estimate potential causal relationships between proteins modified during intentional weight loss and the risk of colorectal, breast, endometrial, gallbladder, liver, and pancreatic cancers. Findings: Nine proteins were modified by the intervention: glycoprotein Nmb; furin; Wnt inhibitory factor 1; toll-like receptor 3; pancreatic prohormone; erb-b2 receptor tyrosine kinase 2; hepatocyte growth factor; endothelial cell specific molecule 1 and Ret proto-oncogene (Holm ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://research-information.bris.ac.uk/en/publications/cee7fdcb-1a02-4d7f-a168-ca060f0193b9Test |
| DOI: | 10.1016/j.ebiom.2024.104977 |
| الإتاحة: | https://doi.org/10.1016/j.ebiom.2024.104977Test https://hdl.handle.net/1983/cee7fdcb-1a02-4d7f-a168-ca060f0193b9Test https://research-information.bris.ac.uk/en/publications/cee7fdcb-1a02-4d7f-a168-ca060f0193b9Test https://authors.elsevier.com/sd/article/S2352396424000124Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.32D3B5B7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.ebiom.2024.104977 |
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