التفاصيل البيبلوغرافية
| العنوان: |
The leukocyte common antigen-related protein tyrosine phosphatase receptor regulates regenerative neurite outgrowth in vivo |
| المؤلفون: |
Youmei Xie, Tracy T. Yeo, Cheng Zhang, Tao Yang, Michelle A. Tisi, Stephen M. Massa, Frank M. Longo |
| المساهمون: |
The Pennsylvania State University CiteSeerX Archives |
| المصدر: |
http://www.jneurosci.org/content/21/14/5130.full.pdfTest. |
| سنة النشر: |
2001 |
| المجموعة: |
CiteSeerX |
| الوصف: |
Drosophila and leech models of nervous system development demonstrate that protein tyrosine phosphatase (PTP) receptors regulate developmental neurite outgrowth. Whether PTP receptors regulate neurite outgrowth in adult systems or in regenerative states remains unknown. The leukocyte common antigenrelated (LAR) receptor is known to be present in rodent dorsal root ganglion (DRG) neurons; therefore, the well established model of postcrush sciatic nerve regeneration was used to test the hypothesis that LAR is required for neurite outgrowth in the adult mammalian nervous system. In uninjured sciatic nerves, no differences in nerve morphology and sensory function were detected between wild-type and LAR-deficient littermate transgenic mice. Sciatic nerve crush resulted in increased LAR protein expression in DRG neurons. In addition, nerve injury led to an increase in the proportion of LAR protein isoforms known |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.320.1275Test; http://www.jneurosci.org/content/21/14/5130.full.pdfTest |
| الإتاحة: |
http://www.jneurosci.org/content/21/14/5130.full.pdfTest |
| حقوق: |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: |
edsbas.32472F6F |
| قاعدة البيانات: |
BASE |
