التفاصيل البيبلوغرافية
| العنوان: |
Working memory modulation using multifocal transcranial direct current stimulation in stable and decliner older adults ; Neuroimaging / Normal brain aging |
| المؤلفون: |
Vaqué‐Alcázar, Lídia, Abellaneda‐Pérez, Kilian, Solé‐Padullés, Cristina, Bargalló, Nuria, Sala‐Llonch, Roser, Bartres‐Faz, David |
| المصدر: |
Alzheimer's & Dementia ; volume 16, issue S5 ; ISSN 1552-5260 1552-5279 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2020 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Background The combination of transcranial direct current stimulation (tDCS) with functional magnetic resonance imaging (fMRI) is able to provide original data about how brain change in aging. Furthermore, tDCS procedures might moderate age‐related brain functional changes associated to cognitive decline. In the present study, we aimed to investigate in which manner two multifocal tDCS procedures based on two distinct working memory (WM) patterns entail capability to modulate neural activity in older adults showing cognitive stability or decline. Method Two multifocal tDCS montages were designed to generate two distinct electric field distributions fitting either ‘compensatory’ or ‘maintenance’ fMRI patterns underlying high WM performance, described in a previous publication from our group (Fernández‐Cabello et al., Neurobiol Aging, 2016). A sham‐controlled crossover study was undertaken on three separate experimental sessions, where 24 healthy elders (mean age: 71.73±2.65 years, 14 females) performed a verbal N‐back task while fMRI data was acquired. During the fMRI acquisitions, tDCS was applied using ‘compensatory’, ‘maintenance’ or sham stimulation in a randomized counter‐balanced order. Each subject was retrospectively classified as showing WM stability (N=12) or decline (N=12) at baseline (i.e. during sham condition) based on the WM scores obtained 4 years before. We studied differences in fMRI between group’ trajectories and across the different tDCS montages. Result There was a significant time*group interaction, where the decliners evidenced a longitudinal progression marked by an over‐activation of non‐related WM areas. Focusing on the stimulation intervention, we identified a significant interaction group (stables vs. decliners) * condition (‘compensatory’ vs. sham). Regarding the specific effects for each group and montage, only in the decliner group, the ‘compensatory’ tDCS induced an activity reduction overlapping posterior cortical regions, whose longitudinal hyperactivation was ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1002/alz.045745 |
| الإتاحة: |
https://doi.org/10.1002/alz.045745Test |
| حقوق: |
http://onlinelibrary.wiley.com/termsAndConditions#vorTest |
| رقم الانضمام: |
edsbas.3240D851 |
| قاعدة البيانات: |
BASE |
