دورية أكاديمية
Multiple hormonal and metabolic deficiency syndrome predicts outcome in heart failure: the T.O.S.CA. Registry
| العنوان: | Multiple hormonal and metabolic deficiency syndrome predicts outcome in heart failure: the T.O.S.CA. Registry |
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| المؤلفون: | Cittadini A, Salzano A, Iacoviello M, Triggiani V, Rengo G, Cacciatore F, Maiello C, Limongelli G, Masarone D, Perticone F, Cimellaro A, Perrone Filardi P, Paolillo S, Mancini A, Volterrani M, Vriz O, Castello R, Passantino A, Campo M, Modesti PA, De Giorgi A, Monte IP, Puzzo A, Ballotta A, D'Assante R, Arcopinto M, Gargiulo P, Sciacqua A, Bruzzese D, Colao A, Napoli R, Suzuki T, Eagle KA, Ventura HO, Marra AM, Bossone E. Saccà L, Monti MG, Matarazzo M, Stagnaro FM, Piccioli L, Lombardi A, Panicara V, Flora M, Golia L, Faga V, Ruocco A, Della Polla D, Franco R, Schiavo A, Gigante A, Spina E, Sicuranza M, Monaco F, Apicella M, Miele C, Campanino AG, Mazza L, Abete R, Farro A, Luciano F, Polizzi R, Ferrillo G, De Luca M, Crisci G, Giardino F, Barbato M, Ranieri B, Ferrara F, Russo V, Malinconico M, Citro R, Guastalamacchia E, Leone M, Giagulli VA, Amarelli C, Mattucci I, Calabrò P, Calabrò R, D’Andrea A, Maddaloni V, Pacileo G, Scarafile R, Belfiore A, Casaretti L, Favuzzi AMR, Di Segni C, Bruno C, Vergani E, Massaro R, F. Grimaldi F, Frigo A, Campo MR, Sorrentino MR, Malandrino D, Manfredini R, Fabbian F, Ragusa L, Caliendo L, Carbone L, Frigiola A, Generali T, Giacomazzi F, De Vincentiis C, Garofalo P, Malizia G, Milano S, Misiano G, Israr MZ, Bernieh D, Cassambai S, Yazaki Y, Heaney LM, Bruzzese D. |
| المساهمون: | Cittadini, A, Salzano, A, Iacoviello, M, Triggiani, V, Rengo, G, Cacciatore, F, Maiello, C, Limongelli, G, Masarone, D, Perticone, F, Cimellaro, A, Perrone Filardi, P, Paolillo, S, Mancini, A, Volterrani, M, Vriz, O, Castello, R, Passantino, A, Campo, M, Modesti, Pa, De Giorgi, A, Monte, Ip, Puzzo, A, Ballotta, A, D'Assante, R, Arcopinto, M, Gargiulo, P, Sciacqua, A, Bruzzese, D, Colao, A, Napoli, R, Suzuki, T, Eagle, Ka, Ventura, Ho, Marra, Am, Bossone E., Saccà L, Monti, Mg, Matarazzo, M, Stagnaro, Fm, Piccioli, L, Lombardi, A, Panicara, V, Flora, M, Golia, L, Faga, V, Ruocco, A, Della Polla, D, Franco, R, Schiavo, A, Gigante, A, Spina, E, Sicuranza, M, Monaco, F, Apicella, M, Miele, C, Campanino, Ag, Mazza, L, Abete, R, Farro, A, Luciano, F, Polizzi, R, Ferrillo, G, De Luca, M, Crisci, G, Giardino, F, Barbato, M, Ranieri, B, Ferrara, F, Russo, V, Malinconico, M, Citro, R, Guastalamacchia, E, Leone, M, Giagulli, Va, Amarelli, C, Mattucci, I, Calabrò, P, Calabrò, R, D’Andrea, A, Maddaloni, V, Pacileo, G, Scarafile, R, Belfiore, A, Casaretti, L, Favuzzi, Amr, Di Segni, C, Bruno, C, Vergani, E, Massaro, R |
| سنة النشر: | 2021 |
| المجموعة: | Università degli Studi di Ferrara: CINECA IRIS |
| مصطلحات موضوعية: | Heart failure, Anabolic deficiency, Multiple hormonal and metabolic deficiency syndrome, Hormones, Prognosis, TOSCA |
| الوصف: | Aims Recent evidence supports the occurrence of multiple hormonal and metabolic deficiency syndrome (MHDS) in chronic heart failure (CHF). However, no large observational study has unequivocally demonstrated its impact on CHF progression and outcome. The T.O.S.CA. (Trattamento Ormonale nello Scompenso CArdiaco; Hormone Treatment in Heart Failure) Registry has been specifically designed to test the hypothesis that MHDS affects morbidity and mortality in CHF patients. Methods and Results The T.O.S.CA. Registry is a prospective, multicentre, observational study involving 19 Italian centres. Thyroid hormones, insulin-like growth factor-1, total testosterone, dehydropianoandrosterone sulfate, insulin resistance, and the presence of diabetes were evaluated. A MHDS was defined as the presence of ≥2 hormone deficiencies (HDs). Primary endpoint was a composite of all-cause mortality and cardiovascular hospitalizations. Four hundred and eighty heart failure patients with ejection fraction ≤45% were enrolled. MHDS or diabetes was diagnosed in 372 patients (77.5%). A total of 271 events (97 deaths and 174 cardiovascular hospitalizations) were recorded, 41% in NO-MHDS and 62% in MHDS (P < 0.001). Median follow-up was of 36 months. MHDS was independently associated with the occurrence of the primary endpoint [hazard ratio 95% (confidence interval), 1.93 (1.37–2.73), P < 0.001] and identified a group of patients with a higher mortality [2.2 (1.28–3.83), P = 0.01], with a graded relation between HDs and cumulative events (P < 0.01). Conclusion MHDS is common in CHF and independently associated with increased all-cause mortality and cardiovascular hospitalization, representing a promising therapeutic target. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/33693736; info:eu-repo/semantics/altIdentifier/wos/WOS:000743510800021; volume:28; issue:15; firstpage:1691; lastpage:1700; numberofpages:10; journal:EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY; https://hdl.handle.net/11392/2470495Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85106962715; https://academic.oup.com/eurjpc/article/28/15/1691/6161355?login=falseTest |
| DOI: | 10.1093/eurjpc/zwab020 |
| الإتاحة: | https://doi.org/10.1093/eurjpc/zwab020Test https://hdl.handle.net/11392/2470495Test https://academic.oup.com/eurjpc/article/28/15/1691/6161355?login=falseTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.321D6C33 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/eurjpc/zwab020 |
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