دورية أكاديمية
The age again in the eye of the COVID-19 storm: evidence-based decision making.
| العنوان: | The age again in the eye of the COVID-19 storm: evidence-based decision making. |
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| المؤلفون: | Martín, María C, Jurado, Aurora, Abad-Molina, Cristina, Orduña, Antonio, Yarce, Oscar, Navas, Ana M, Cunill, Vanesa, Escobar, Danilo, Boix, Francisco, Burillo-Sanz, Sergio, Vegas-Sánchez, María C, Jiménez-de Las Pozas, Yesenia, Melero, Josefa, Aguilar, Marta, Sobieschi, Oana Irina, López-Hoyos, Marcos, Ocejo-Vinyals, Gonzalo, San Segundo, David, Almeida, Delia, Medina, Silvia, Fernández, Luis, Vergara, Esther, Quirant, Bibiana, Martínez-Cáceres, Eva, Boiges, Marc, Alonso, Marta, Esparcia-Pinedo, Laura, López-Sanz, Celia, Muñoz-Vico, Javier, López-Palmero, Serafín, Trujillo, Antonio, Álvarez, Paula, Prada, Álvaro, Monzón, David, Ontañón, Jesús, Marco, Francisco M, Mora, Sergio, Rojo, Ricardo, González-Martínez, Gema, Martínez-Saavedra, María T, Gil-Herrera, Juana, Cantenys-Molina, Sergi, Hernández, Manuel, Perurena-Prieto, Janire, Rodríguez-Bayona, Beatriz, Martínez, Alba, Ocaña, Esther, Molina, Juan |
| سنة النشر: | 2021 |
| المجموعة: | Sistema Sanitario Público de Andalucía (SSPA): Repositorio |
| مصطلحات موضوعية: | Area under the curve, COVID-19, Cut-off points, Immunity, Immunosenescence, Lockdown, Lymphocytes, Renin-angiotensin-aldosterone system inhibitors, Severe acute respiratory syndrome coronavirus 2 |
| الوصف: | One hundred fifty million contagions, more than 3 million deaths and little more than 1 year of COVID-19 have changed our lives and our health management systems forever. Ageing is known to be one of the significant determinants for COVID-19 severity. Two main reasons underlie this: immunosenescence and age correlation with main COVID-19 comorbidities such as hypertension or dyslipidaemia. This study has two aims. The first is to obtain cut-off points for laboratory parameters that can help us in clinical decision-making. The second one is to analyse the effect of pandemic lockdown on epidemiological, clinical, and laboratory parameters concerning the severity of the COVID-19. For these purposes, 257 of SARSCoV2 inpatients during pandemic confinement were included in this study. Moreover, 584 case records from a previously analysed series, were compared with the present study data. Concerning the characteristics of lockdown series, mild cases accounted for 14.4, 54.1% were moderate and 31.5%, severe. There were 32.5% of home contagions, 26.3% community transmissions, 22.5% nursing home contagions, and 8.8% corresponding to frontline worker contagions regarding epidemiological features. Age > 60 and male sex are hereby confirmed as severity determinants. Equally, higher severity was significantly associated with higher IL6, CRP, ferritin, LDH, and leukocyte counts, and a lower percentage of lymphocyte, CD4 and CD8 count. Comparing this cohort with a previous 584-cases series, mild cases were less than those analysed in the first moment of the pandemic and dyslipidaemia became more frequent than before. IL-6, CRP and LDH values above 69 pg/mL, 97 mg/L and 328 U/L respectively, as well as a CD4 T-cell count below 535 cells/μL, were the best cut-offs predicting severity since these parameters offered reliable areas under the curve. Age and sex together with selected laboratory parameters on admission can help us predict COVID-19 severity and, therefore, make clinical and resource management decisions. Demographic ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1742-4933 |
| العلاقة: | http://hdl.handle.net/10668/17811Test; PMC8134808; https://immunityageing.biomedcentral.com/counter/pdf/10.1186/s12979-021-00237-wTest; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134808/pdfTest |
| DOI: | 10.1186/s12979-021-00237-w |
| الإتاحة: | https://doi.org/10.1186/s12979-021-00237-wTest http://hdl.handle.net/10668/17811Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134808/pdfTest |
| حقوق: | Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0Test/ ; open access |
| رقم الانضمام: | edsbas.31B7B6E4 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 17424933 |
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| DOI: | 10.1186/s12979-021-00237-w |