دورية أكاديمية
IGF2: an endocrine hormone to improve islet transplant survival
| العنوان: | IGF2: an endocrine hormone to improve islet transplant survival |
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| المؤلفون: | Hughes, A., Rojas-Canales, D., Drogemuller, C., Voelcker, N., Grey, S., Coates, P. |
| المصدر: | http://dx.doi.org/10.1530/joe-13-0557Test. |
| بيانات النشر: | BioScientifica |
| سنة النشر: | 2014 |
| المجموعة: | The University of Adelaide: Digital Library |
| مصطلحات موضوعية: | insulin-like growth factor, apoptosis, islets, cell survival, islet transplantation |
| الوصف: | In the week following pancreatic islet transplantation, up to 50% of transplanted islets are lost due to apoptotic cell death triggered by hypoxic and pro-inflammatory cytokine-mediated cell stress. Thus, therapeutic approaches designed to protect islet cells from apoptosis could significantly improve islet transplant success. IGF2 is an anti-apoptotic endocrine protein that inhibits apoptotic cell death through the mitochondrial (intrinsic pathway) or via antagonising activation of pro-inflammatory cytokine signalling (extrinsic pathway), in doing so IGF2 has emerged as a promising therapeutic molecule to improve islet survival in the immediate post-transplant period. The development of novel biomaterials coated with IGF2 is a promising strategy to achieve this. This review examines the mechanisms mediating islet cell apoptosis in the peri- and post-transplant period and aims to identify the utility of IGF2 to promote islet survival and enhance long-term insulin independence rates within the setting of clinical islet transplantation. ; Amy Hughes, Darling Rojas-Canales, Chris Drogemuller, Nicolas H Voelcker, Shane T Grey and P T H Coates |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0022-0795 1479-6805 |
| العلاقة: | Journal of Endocrinology, 2014; 221(2):R41-R48; http://hdl.handle.net/2440/92579Test; Drogemuller, C. [0000-0001-9770-4845]; Grey, S. [0000-0003-2160-1625] |
| DOI: | 10.1530/JOE-13-0557 |
| الإتاحة: | https://doi.org/10.1530/JOE-13-0557Test https://doi.org/10.1530/joe-13-0557Test http://hdl.handle.net/2440/92579Test |
| حقوق: | © 2014 Society for Endocrinology |
| رقم الانضمام: | edsbas.31B794C1 |
| قاعدة البيانات: | BASE |
| تدمد: | 00220795 14796805 |
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| DOI: | 10.1530/JOE-13-0557 |