دورية أكاديمية
Short-Term Collagen Nerve Wrapping Facilitates Motor and Sensory Recovery from Nerve Degeneration in a Sciatic Nerve Injury Rat Model
| العنوان: | Short-Term Collagen Nerve Wrapping Facilitates Motor and Sensory Recovery from Nerve Degeneration in a Sciatic Nerve Injury Rat Model |
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| المؤلفون: | Sonohata,Motoki, Doi,Atsushi, Uchihashi,Kazuyoshi, Hashimoto,Akira, Kii,Sakumo, Inoue,Takao, Mawatari,Masaaki |
| بيانات النشر: | Dove Press |
| سنة النشر: | 2023 |
| المجموعة: | Dove Medical Press |
| مصطلحات موضوعية: | Journal of Pain Research |
| الوصف: | Motoki Sonohata,1,2,* Atsushi Doi,3,* Kazuyoshi Uchihashi,4 Akira Hashimoto,2 Sakumo Kii,1 Takao Inoue,5 Masaaki Mawatari1 1Department of Orthopaedic Surgery, Faculty of Medicine, Saga University, Saga, Japan; 2Department of Orthopaedic Surgery, Saga Central Hospital, Saga, Japan; 3Department of Rehabilitation, Kumamoto Health Science University, Kumamoto, Japan; 4Department of Surgical Pathology, National Hospital Organization Saga Hospital, Saga, Japan; 5Organization of Research Initiatives, Yamaguchi University, Yamaguchi, Japan*These authors contributed equally to this workCorrespondence: Atsushi Doi, Department of Rehabilitation, Kumamoto Health Science University, 324, Izumi, Kumamoto-kitaku, Kumamoto, 861-5598, Japan, Tel +81-96-275-2111, Email atsushidoi01@gmail.comPurpose: This study used a sciatic nerve injury rat model to investigate the short-term effects of a polyglycolic acid (PGA)-collagen tube for nerve injury in continuity.Materials and Methods: Sixteen female Wistar rats (6– 8 weeks) were used, and the left sciatic nerve was crushed with a Sugita aneurysm clip. Sciatic nerve model rats were randomly categorized into two groups (n = 8; control group, n = 8; nerve wrapping group). Then, we measured four sensory thresholds, magnetically stimulated the lumbar region to induce motor-evoked potentials (MEPs), and evaluated the sciatic nerve histopathologically.Results: In the sensory thresholds, there were significant differences for the main effect in 250 and 2000 Hz stimulation (p = 0.048 and 0.006, respectively). Further, a significant difference was observed with 2000 Hz stimulation at 1 week (p = 0.003). In the heat stimulation, there were significant differences for the main effect in both weeks and groups (p = 0.0002 and 0.0185, respectively). The post-hoc test showed a significant difference between groups only in 2W (p = 0.0283). Three weeks after the surgery, both 2nd and 3rd MEPs waves-related latencies in the nerve wrapping group were significantly shorter than those in the control ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | https://www.dovepress.com/short-term-collagen-nerve-wrapping-facilitates-motor-and-sensory-recov-peer-reviewed-fulltext-article-JPRTest |
| الإتاحة: | https://doi.org/10.2147/JPR.S401126Test https://www.dovepress.com/short-term-collagen-nerve-wrapping-facilitates-motor-and-sensory-recov-peer-reviewed-fulltext-article-JPRTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.31574F7 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |