دورية أكاديمية
Narrow resection margins are not associated with mortality or recurrence in patients with Merkel cell carcinoma: a retrospective study
| العنوان: | Narrow resection margins are not associated with mortality or recurrence in patients with Merkel cell carcinoma: a retrospective study |
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| المؤلفون: | Jaouen, Frédéric, Kervarrec, Thibault, Caille, Agnès, Le Corre, Yannick, Dreno, Brigitte, Esteve, Eric, Wierzbicka-Hainaut, Ewa, Maillard, Hervé, Dinulescu, Monica, Blom, Astrid, Saïag, Philippe, Samimi, Mahtab |
| المساهمون: | Université de Tours (UT), Service de dermatologie, Service de Pathologie CHRU Tours, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Infectiologie et Santé Publique (UMR ISP), Université de Tours (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), MethodS in Patients-centered outcomes and HEalth ResEarch (SPHERE), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques, Université de Nantes (UN)-Université de Nantes (UN), Centre d’Investigation Clinique Tours CIC 1415 (CIC ), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Hôpital Bretonneau-Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de dermatologie CHU Angers, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Service de dermatologie Nantes, Université de Nantes (UN)-Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes), Service de Dermatologie Orléans, Centre Hospitalier Régional d'Orléans (CHRO), Département de Dermatologie CHU Poitiers, Centre hospitalier universitaire de Poitiers = Poitiers University Hospital (CHU de Poitiers La Milétrie ), Service de dermatologie CH Le Mans, Centre Hospitalier Le Mans (CH Le Mans), Service de Dermatologie Rennes = Dermatology Rennes, Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Ponchaillou, Service de Dermatologie Générale et Oncologique AP-HP Hôpital Ambroise-Paré, Paris, Hôpital Ambroise Paré AP-HP, Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ) |
| المصدر: | ISSN: 0190-9622. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2021 |
| المجموعة: | Université de Versailles Saint-Quentin-en-Yvelines: HAL-UVSQ |
| مصطلحات موضوعية: | General surgery, Merkel Cell Carcinoma, Mortality, Prognosis, Skin neoplasms, Surgical margins, Wide Local Excision, [SDV]Life Sciences [q-bio], [SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology, [SDV.CAN]Life Sciences [q-bio]/Cancer |
| الوصف: | International audience ; Background: Wide local excision constitutes the standard of care for Merkel cell carcinoma, but the optimal margin width remains controversial.Objectives: To assess whether narrow margins (0.5 - 1 cm) were associated with outcome.Methods: Patients were recruited from a retrospective French multicentric cohort and included if they had had excision of primary tumor with minimum lateral margins of 0.5 cm. Factors associated with mortality and recurrence were assessed by multivariate regression.Results: Among the 214 patients included, 58 (27.1%) had undergone excision with narrow margins (0.5-1cm) versus 156 (72.9%) with wide margins (>1cm). During a median follow-up of 50.7 months, cancer-specific survival did not differ between groups [5-year specific survival rate 76.8% (95% CI 61.7-91.9) and 76.2% (95% CI 68.8-83.6)]. Overall survival, any recurrence-free survival and local recurrence-free survival did not significantly differ between groups. Cancer-specific mortality was associated with age, male sex, AJCC stage III, positive margins.Limitations: Retrospective design, heterogenous baseline characteristics between groups.Conclusion: Excision with narrow margins was not associated with outcome in this cohort, in which most patients had clear margins and post-operative radiation therapy. Residual tumor, mostly found on deep surgical margins, was independently associated with prognosis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/33253832; hal-03151003; https://hal.inrae.fr/hal-03151003Test; https://hal.inrae.fr/hal-03151003/documentTest; https://hal.inrae.fr/hal-03151003/file/S0190962220330796.pdfTest; PII: S0190-9622(20)33079-6; PUBMED: 33253832; WOS: 000644498500008 |
| DOI: | 10.1016/j.jaad.2020.11.038 |
| الإتاحة: | https://doi.org/10.1016/j.jaad.2020.11.038Test https://hal.inrae.fr/hal-03151003Test https://hal.inrae.fr/hal-03151003/documentTest https://hal.inrae.fr/hal-03151003/file/S0190962220330796.pdfTest |
| حقوق: | http://creativecommons.org/licenses/by-ncTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.314FA4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.jaad.2020.11.038 |
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