التفاصيل البيبلوغرافية
| العنوان: |
Differential associations of risk factors with severe and non‐severe hypoglycaemia: the Hypoglycaemia Assessment Tool prospective observational study in people with insulin‐treated type 1 diabetes and type 2 diabetes |
| المؤلفون: |
He, Ying, Kunutsor, Setor K., Kingsnorth, Andrew P., Gillies, Clare, Choudhary, Pratik, Khunti, Kamlesh, Zaccardi, Francesco |
| المساهمون: |
National Institute for Health Research Applied Research Collaboration East of England |
| المصدر: |
Diabetes, Obesity and Metabolism ; volume 26, issue 8, page 3361-3370 ; ISSN 1462-8902 1463-1326 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2024 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Aim To assess the differential association of risk factors with severe and non‐severe hypoglycaemia. Materials and Methods The Hypoglycaemia Assessment Tool study evaluated the risk of hypoglycaemia over a 4‐week period in patients with type 1 diabetes (T1D) and type 2 diabetes (T2D) on insulin in 24 countries. Negative binomial regressions were applied to examine the associations of several risk factors with severe and non‐severe hypoglycaemia. Results The median age was 41 years in 5949 patients with T1D and 62 years in 12 914 patients with T2D. The 4‐week rates of non‐severe hypoglycaemic were 5.57 and 1.40 episodes per person in T1D and T2D, respectively; the corresponding rates for severe hypoglycaemia were 0.94 and 0.30. The excess risk was 42% higher for severe than non‐severe hypoglycaemia in females versus males with T2D; 27% higher in patients with T2D with versus without a continuous glucose monitoring (CGM); and 47% lower in patients with T1D with versus without an insulin pump. The excess risk also differed across geographical areas and was marginally lower for severe than non‐severe hypoglycaemia for higher values of HbA1c in patients with T2D. Associations with severity of hypoglycaemia were not different for age, diabetes and insulin therapy duration, previous hypoglycaemic episodes and insulin regimen. Conclusions The risk of severe versus non‐severe hypoglycaemia differs in patients with T1D and T2D; sex, the use of a CGM and insulin pump, and geographical areas were differently associated with one type of hypoglycaemia than the other. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1111/dom.15677 |
| الإتاحة: |
https://doi.org/10.1111/dom.15677Test |
| حقوق: |
http://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: |
edsbas.30FD700E |
| قاعدة البيانات: |
BASE |
