التفاصيل البيبلوغرافية
| العنوان: |
Synthesis, spectroscopic and antibacterial investigations of new hydroxy ethers and heterocyclic coumarin derivatives |
| المؤلفون: |
Hamdi, Naceur, Saoud, Mustapha, Romerosa, Antonio, Hassen, Rached Ben |
| المصدر: |
Journal of Heterocyclic Chemistry ; volume 45, issue 6, page 1835-1842 ; ISSN 0022-152X 1943-5193 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2008 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
magnified image The reactions between oligoethylene glycol diglycidyl ethers 2a‐c with both 7‐hydroxy‐4‐methyl‐2 H ‐chromen‐2‐one and 4‐hydroxy‐2 H ‐chromen‐2‐one lead to new hydroxy ethers 3 and 4 containing coumarin moieties in good yield. The synthesis of 3‐(3‐(dimethylamino)acryloyl)‐4‐hydroxy‐2 H ‐chromen‐2‐one 5 and new heterocyclic compounds 4‐hydroxy‐3‐(1 H ‐pyrazol‐3‐yl)‐2 H ‐chromen‐2‐one 6a , 4‐hydroxy‐3‐(1‐phenylpyrazol‐3‐yl)‐2 H ‐chromen‐2‐one 6b and 4‐hydroxy‐3‐(isoxazol‐3‐yl)‐2 H ‐chromen‐2‐one 6c is also described. All compounds were characterized by 1 H NMR, 13 C{ 1 H} NMR, 2D‐ 1 H‐ 13 C HMBC, 2D‐ 1 H NOESY NMR, IR, and MS spectroscopy. Additionally, the antibacterial activity of the new products containing coumarin moiety was evaluated. This activity is clearly dependent on the chemical structure of compounds. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1002/jhet.5570450644 |
| الإتاحة: |
https://doi.org/10.1002/jhet.5570450644Test |
| حقوق: |
http://onlinelibrary.wiley.com/termsAndConditions#vorTest |
| رقم الانضمام: |
edsbas.30FB93B4 |
| قاعدة البيانات: |
BASE |
