دورية أكاديمية
CDK4, CDK6/cyclin-D1 Complex Inhibition and Radiotherapy for Cancer Control: A Role for Autophagy
| العنوان: | CDK4, CDK6/cyclin-D1 Complex Inhibition and Radiotherapy for Cancer Control: A Role for Autophagy |
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| المؤلفون: | Valerio Nardone, Marcella Barbarino, Antonio Angrisani, Pierpaolo Correale, Pierpaolo Pastina, Salvatore Cappabianca, Alfonso Reginelli, Luciano Mutti, Clelia Miracco, Rocco Giannicola, Antonio Giordano, Luigi Pirtoli |
| المصدر: | International Journal of Molecular Sciences, Vol 22, Iss 8391, p 8391 (2021) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2021 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | cyclin inhibitors, radiotherapy, autophagy, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | The expanding clinical application of CDK4- and CDK6-inhibiting drugs in the managements of breast cancer has raised a great interest in testing these drugs in other neoplasms. The potential of combining these drugs with other therapeutic approaches seems to be an interesting work-ground to explore. Even though a potential integration of CDK4 and CDK6 inhibitors with radiotherapy (RT) has been hypothesized, this kind of approach has not been sufficiently pursued, neither in preclinical nor in clinical studies. Similarly, the most recent discoveries focusing on autophagy, as a possible target pathway able to enhance the antitumor efficacy of CDK4 and CDK6 inhibitors is promising but needs more investigations. The aim of this review is to discuss the recent literature on the field in order to infer a rational combination strategy including cyclin-D1/CDK4-CDK6 inhibitors, RT, and/or other anticancer agents targeting G1-S phase cell cycle transition. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| العلاقة: | https://www.mdpi.com/1422-0067/22/16/8391Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test; https://doaj.org/article/243d17d65b1c4011b4886e1439439fa1Test |
| DOI: | 10.3390/ijms22168391 |
| الإتاحة: | https://doi.org/10.3390/ijms22168391Test https://doaj.org/article/243d17d65b1c4011b4886e1439439fa1Test |
| رقم الانضمام: | edsbas.30C09DD2 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms22168391 |