دورية أكاديمية
أعرض في EDS

Staging of regional nodes in AJCC stage I and II melanoma: 18FDG PET imaging versus sentinel node detection.

التفاصيل البيبلوغرافية
العنوان: Staging of regional nodes in AJCC stage I and II melanoma: 18FDG PET imaging versus sentinel node detection.
المؤلفون: Belhocine, Tarik, Pierard, Gérald, De Labrassinne, Michel, Lahaye, Thierry, Rigo, Pierre
المصدر: Oncologist, 7 (4), 271-8 (2002)
بيانات النشر: AlphaMed Company, Inc.
سنة النشر: 2002
المجموعة: University of Liège: ORBi (Open Repository and Bibliography)
مصطلحات موضوعية: Adult, Aged, Disease Progression, Extremities/blood supply/pathology, False Positive Reactions, Female, Fluorodeoxyglucose F18/diagnostic use, Follow-Up Studies, Head and Neck Neoplasms/diagnosis/pathology, Humans, Injections, Intravenous, Lymph Nodes/pathology/radionuclide imaging/surgery, Male, Melanoma/diagnosis/pathology, Middle Aged, Neoplasm Staging, Predictive Value of Tests, Radiopharmaceuticals/diagnostic use, Recurrence, Sensitivity and Specificity, Sentinel Lymph Node Biopsy, Tomography, Emission-Computed, Human health sciences, Radiology, nuclear medicine & imaging, Sciences de la santé humaine, Radiologie, médecine & imagerie nucléaire
الوصف: peer reviewed ; PRIMARY PURPOSE: The staging of regional nodes by means of sentinel node detection has been shown to accurately detect subclinical nodal metastases from cutaneous melanoma. On the other hand, the oncological applications of 18F-fluoro-2-deoxy-D-glucose positron emission tomography (18FDG PET) are, nowadays, firmly established. However, the sensitivity of such metabolic imaging for staging the regional nodes in primary melanoma remains debatable. We prospectively assessed the actual value of PET for detecting sentinel node metastases in 21 consecutive patients presenting with early-stage melanoma. MATERIALS AND METHODS: Twenty-one melanoma patients scheduled for lymphatic mapping and sentinel lymphadenectomy underwent fully corrected whole-body PET using 18FDG. In all cases, the disease was initially classified as either stage I or II, from the latest version of the American Joint Committee on Cancer staging system. The sentinel node detection was systematically performed within the week following the PET scan. Serial sections of the sentinel nodes were analyzed by both conventional pathology and immunohistochemical staining. Metastatic sentinel nodes were also assessed for the size of tumor deposits and the degree of nodal involvement (focal, partial, or massive). The median follow-up time was 12 months. RESULTS: Six of the 21 patients (28.5%) had an involved sentinel node. PET was positive in only one case with a sentinel node >1 cm. In the five other cases, the sentinel nodes missed by PET were <1 cm with focal and/or partial involvements. One patient, free of regional nodal metastases in both sentinel node detection and PET imaging, had, however, a same-basin recurrence 3 months later. In another case, PET had one false positive result. Overall, the sentinel detection of subclinical nodal metastases had a sensitivity of 86%. PET detected only 14% of sentinel node metastases. CONCLUSIONS: Sentinel node detection remains the procedure of choice for detecting subclinical lymph node ...
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 1083-7159
1549-490X
العلاقة: urn:issn:1083-7159; urn:issn:1549-490X; https://orbi.uliege.be/handle/2268/11920Test; info:hdl:2268/11920; https://orbi.uliege.be/bitstream/2268/11920/1/STAGING%20OF%20REGIONAL.pdfTest; scopus-id:2-s2.0-0036058601; info:pmid:12185291
DOI: 10.1634/theoncologist.7-4-271
الإتاحة: https://doi.org/10.1634/theoncologist.7-4-271Test
https://orbi.uliege.be/handle/2268/11920Test
https://orbi.uliege.be/bitstream/2268/11920/1/STAGING%20OF%20REGIONAL.pdfTest
حقوق: open access ; http://purl.org/coar/access_right/c_abf2Test ; info:eu-repo/semantics/openAccess
رقم الانضمام: edsbas.3065982E
قاعدة البيانات: BASE
الوصف
تدمد:10837159
1549490X
DOI:10.1634/theoncologist.7-4-271