التفاصيل البيبلوغرافية
| العنوان: |
Specific Nanodrug for Diabetic Chronic Wounds Based on Antioxidase-Mimicking MOF-818 Nanozymes |
| المؤلفون: |
Daiyong Chao (11414645), Qing Dong (5624), Zhixuan Yu (14103534), Desheng Qi (6562076), Minghua Li (277040), Lili Xu (257856), Ling Liu (143030), Youxing Fang (1609759), Shaojun Dong (271860) |
| سنة النشر: |
2022 |
| مصطلحات موضوعية: |
Biochemistry, Medicine, Biotechnology, Infectious Diseases, Chemical Sciences not elsewhere classified, various wound treatments, significant economic burden, oxidative stress microenvironment, metal organic framework, entails substantial inconvenience, current clinical treatments, chronic wound healing, ineffective inflammation phase, effective antioxidative system, diabetic chronic wounds, chronic wounds, inflammation phase, proliferation phase, normal wounds, diabetic rats, gel system, specific nanodrug, primary difference, persistent pain, natural transition, like activity, common complication, antioxidant enzyme |
| الوصف: |
Chronic wound is a common complication for diabetic patients, which entails substantial inconvenience, persistent pain, and significant economic burden to patients. However, current clinical treatments for diabetic chronic wounds remain unsatisfactory. A prolonged but ineffective inflammation phase in chronic wounds is the primary difference between diabetic chronic wounds and normal wounds. Herein, we present an effective antioxidative system (MOF/Gel) for chronic wound healing of diabetic rats through integrating a metal organic framework (MOF) nanozyme with antioxidant enzyme-like activity with a hydrogel (Gel). MOF/Gel can continuously scavenge reactive oxygen species to modulate the oxidative stress microenvironment in diabetic chronic wounds, which leads to a natural transition from the inflammation phase to the proliferation phase. Impressively, the efficacy of one-time-applied MOF/Gel was comparable to that of the human epidermal growth factor Gel, a widely used clinical drug for various wound treatments. Such an effective, safe, and convenient MOF/Gel system can meet complex clinical demands. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/journal_contribution/Specific_Nanodrug_for_Diabetic_Chronic_Wounds_Based_on_Antioxidase-Mimicking_MOF-818_Nanozymes/21720164Test |
| DOI: |
10.1021/jacs.2c09663.s001 |
| الإتاحة: |
https://doi.org/10.1021/jacs.2c09663.s001Test |
| حقوق: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.304343C1 |
| قاعدة البيانات: |
BASE |
