التفاصيل البيبلوغرافية
| العنوان: |
Effect of fasedienol (PH94B) pherine nasal spray and steroidal hormones on electrogram responses and autonomic nervous system activity in healthy adult volunteers |
| المؤلفون: |
Monti, Louis, Hanover, Rita, Salmán, Ester, Baker, Ross A., Lappalainen, Jaakko, Smith, Mark |
| المصدر: |
Human Psychopharmacology: Clinical and Experimental ; volume 39, issue 2 ; ISSN 0885-6222 1099-1077 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2024 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Objective Fasedienol (PH94B) is a pherine compound formulated as a nasal spray that is hypothesized to regulate olfactory‐amygdala circuits of fear and anxiety. Fasedienol's effect on the local electrogram of nasal chemosensory neurons (EGNR) and autonomic nervous system (ANS) responses versus steroidal hormones and controls in healthy adults is reported. Methods Eight males and 8 females randomly received aerosolized control (propylene glycol) and study drugs (fasedienol, 17β‐estradiol, progesterone, cortisol, and testosterone, 0.4 μg each in propylene glycol) onto the nasal septum mucosal lining at 30‐min intervals over 2 sessions. EGNR was continuously monitored; autonomic parameters were recorded before and after administration. Results Fasedienol significantly increased EGNR amplitude (males: 5.0 vs. 0.6 mV, p < 0.001; females:5.7 vs. 0.6 mV, p < 0.001), and rapidly reduced respiratory rate ( p < 0.05), heart rate ( p < 0.01), and electrodermal activity ( p < 0.05) versus control. EGNR and ANS responses after steroidal hormone administration were similar to control. 81% reported feeling less tense/more relaxed after receiving fasedienol, but not after receiving either control or steroidal hormones. Conclusions Intranasal fasedienol, but not control or steroidal hormones, activated EGNR and rapidly reduced ANS responses, consistent with sympatholytic effects. Combined with subjective reports, results suggest fasedienol may provide acute relief in anxiety conditions. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1002/hup.2892 |
| الإتاحة: |
https://doi.org/10.1002/hup.2892Test |
| حقوق: |
http://creativecommons.org/licenses/by-nc/4.0Test/ |
| رقم الانضمام: |
edsbas.302FAC25 |
| قاعدة البيانات: |
BASE |
