التفاصيل البيبلوغرافية
| العنوان: |
Cdc7 overexpression is an independent prognostic marker and a potential therapeutic target in colorectal cancer |
| المؤلفون: |
Melling, Nathaniel, Muth, Johanna, Simon, Ronald, Bokemeyer, Carsten, Terracciano, Luigi, Sauter, Guido, Izbicki, Jakob, Marx, Andreas |
| بيانات النشر: |
BioMed Central Ltd. |
| سنة النشر: |
2015 |
| المجموعة: |
BioMed Central |
| مصطلحات موضوعية: |
Biological markers, Cell cycle checkpoints, Colorectal neoplasms, Immunohistochemistry, Prognosis |
| الوصف: |
Background Cdc7 is a widely expressed protein kinase implicated in cell division, cell cycle checkpoint mechanisms and cancer progression. Recently, it has been suggested as a target for anti-cancer therapy. Methods To determine the relationship of Cdc7 protein expression with tumor phenotype, molecular features and prognosis, 1800 colorectal carcinomas were analyzed by immunohistochemistry on a tissue microarray. Results Cdc7 expression was considered negative in 33.6 %, weak in 57.2 % and strong in 9.2 % of 1711 interpretable CRCs. Loss of Cdc7 expression was significantly associated with high tumor stage ( p < 0.0001) and high tumor grade ( p = 0.0077), but was unrelated to the nodal status ( p = 0.5957). Moreover, a link between Cdc7 expression and the tubular histological tumor type was seen ( p < 0.0001). p53 and Cdc7 expression were significantly linked to each other ( p = 0.0013). In a multivariate survival analysis, strong Cdc7 expression of CRC was an independent marker of improved patient survival ( p = 0.0031). Conclusion Our data show that Cdc7 is highly expressed in CRC and a potential therapeutic target in a subset of cancers with high p53 expression. Moreover, our findings strongly argue for a clinical utility of Cdc7 immunostaining as an independent prognostic biomarker in colorectal cancer enabling to select patients for adjuvant treatment. |
| نوع الوثيقة: |
report |
| اللغة: |
English |
| العلاقة: |
http://www.diagnosticpathology.org/content/10/1/125Test |
| الإتاحة: |
http://www.diagnosticpathology.org/content/10/1/125Test |
| حقوق: |
Copyright 2015 Melling et al. |
| رقم الانضمام: |
edsbas.301B1A40 |
| قاعدة البيانات: |
BASE |
