دورية أكاديمية
Cerebrospinal fluid free light chains compared to oligoclonal bands as biomarkers in multiple sclerosis
| العنوان: | Cerebrospinal fluid free light chains compared to oligoclonal bands as biomarkers in multiple sclerosis |
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| المؤلفون: | Gaetani L., Di Carlo M., Brachelente G., Valletta F., Eusebi P., Mancini A., Gentili L., Borrelli A., Calabresi P., Sarchielli P., Ferri C., Villa A., Di Filippo M. |
| المساهمون: | Gaetani, L., Di Carlo, M., Brachelente, G., Valletta, F., Eusebi, P., Mancini, A., Gentili, L., Borrelli, A., Calabresi, P., Sarchielli, P., Ferri, C., Villa, A., Di Filippo, M. |
| سنة النشر: | 2020 |
| المجموعة: | IRIS Università degli Studi di Perugia |
| مصطلحات موضوعية: | Biomarker, Cerebrospinal fluid, Free light chain, Kappa index, Multiple sclerosis |
| الوصف: | Cerebrospinal fluid (CSF) free light chains (FLC) may be an alternative biomarker to oligoclonal bands (OCB) in multiple sclerosis (MS). Herein, we compared the diagnostic accuracy of CSF OCB and FLC and we tested the prognostic value of FLC in a cohort of 64 MS patients and 106 controls. A κ-index >7.83 was more sensitive but less specific than OCB in discriminating MS patients from controls. Additionally, a κ-index >10.61 performed better than OCB in the discrimination between MS and controls with inflammatory neurological diseases (p <.001). In clinically isolated syndrome (CIS) patients, a κ-index >10.61 significantly predicted time to conversion to MS (p =.020). κ-index might be a valid alternative to OCB as a diagnostic biomarker for MS and might also be a prognostic marker in CIS. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/31743879; info:eu-repo/semantics/altIdentifier/wos/WOS:000510528000011; volume:339; firstpage:577108; journal:JOURNAL OF NEUROIMMUNOLOGY; http://hdl.handle.net/11391/1458611Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85074976879; www.elsevier.com/locate/jneuroim |
| DOI: | 10.1016/j.jneuroim.2019.577108 |
| الإتاحة: | https://doi.org/10.1016/j.jneuroim.2019.577108Test http://hdl.handle.net/11391/1458611Test |
| رقم الانضمام: | edsbas.2FEEDA7D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.jneuroim.2019.577108 |
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