دورية أكاديمية
Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset
| العنوان: | Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset |
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| المؤلفون: | Sævarsdóttir, Sædís, Stefansdottir, Lilja, Sulem, P., Thorleifsson, G., Ferkingstad, E., Rutsdottir, G., Glintborg, B., Westerlind, H., Gröndal, Gerður María, Loft, I.C., Sorensen, S.B., Lie, B.A., Brink, M., Arlestig, L., Arnthorsson, A.O., Baecklund, E., Banasik, K., Bank, S., Bjorkman, L.I., Ellingsen, T., Erikstrup, C., Frei, O., Gjertsson, I., Gudbjartsson, D.F., Gudjonsson, S.A., Halldorsson, G.H., Hendricks, O., Hillert, J., Hogdall, E., Jacobsen, Sø, Jensen, D.V., Jonsson, Helgi, Kastbom, A., Kockum, I., Kristensen, S., Kristjansdottir, Helga, Larsen, M.H., Linauskas, A., Hauge, E.-M., Loft, A.G., Lúðvíksson, Björn Rúnar, Lund, S.H., Markusson, Þorsteinn, Masson, G., Melsted, P., Moore, K.H.S., Munk, H., Nielsen, K.R., Norddahl, G.L., Oddsson, A., Olafsdottir, T.A., Olason, P.I., Olsson, T., Ostrowski, S.R., Hørslev-Petersen, K., Rognvaldsson, S., Sanner, H., Silberberg, G.N., Stefansson, H., Sørensen, E., Sørensen, I.J., Turesson, C., Bergman, T., Alfredsson, L., Kvien, T.K., Brunak, Sø, Steinsson, K., Andersen, V., Andreassen, O.A., Rantapää-Dahlqvist, S., Hetland, M.L., Klareskog, L., Askling, J., Padyukov, L., Pedersen, O.B.V., Thorsteinsdottir, U., Jonsdottir, I., Stefánsson, Kári |
| المساهمون: | Faculty of Medicine, Faculty of Industrial Engineering, Mechanical Engineering and Computer Science, Faculty of Physical Sciences, Health Sciences, Landspitali - The National University Hospital of Iceland |
| سنة النشر: | 2022 |
| المجموعة: | Opin vísindi (Iceland) |
| مصطلحات موضوعية: | Gigtarlæknisfræði, Ónæmisfræði, autoantibodies, polymorphism, genetic, rheumatoid arthritis, Genome-Wide Association Study, Protein Tyrosine Phosphatase, Non-Receptor Type 22/genetics, Interferon-alpha, Humans, Signal Transduction/genetics, Arthritis, Rheumatoid/genetics, Genetic Predisposition to Disease/genetics, Janus Kinases/genetics, Proteomics, STAT Transcription Factors/genetics, General Biochemistry,Genetics and Molecular Biology, Rheumatology, Immunology and Allergy, Immunology |
| الوصف: | Funding Information: Funding The study was funded by NORDFORSK (grant agreement no. 90825, project NORA), the Swedish Research Council (2018-02803), the Swedish innovation Agency (Vinnova), Innovationsfonden and The Research Council of Norway, Region Stockholm-Karolinska Institutet and Region Västerbotten (ALF), the Danish Rheumatism Association (R194-A6956), the Swedish Brain Foundation, Nils and Bibbi Jensens Foundation, the Knut and Alice Wallenberg Foundation, Margaretha af Ugglas Foundation, the South-Eastern Heath Region of Norway, the Health Research Fund of Central Denmark Region, Region of Southern Denmark, the A.P. Moller Foundation for the Advancement of Medical Science, the Colitis-Crohn Foreningen, the Novo Nordisk Foundation (NNF15OC0016932), Aase og Ejnar Danielsens Fond, Beckett-Fonden, Augustinus Fonden, Knud and Edith Eriksens Mindefond, Laege Sofus Carl Emil Friis and Hustru Olga Doris Friis’ Legat, the Psoriasis Forskningsfonden, the University of Aarhus, the Danish Rheumatism Association (R194-A6956, A1923, A3037 and A3570 – www. gigtforeningen.dk), Region of Southern Denmark’s PhD Fund, 12/7725 (www.regionsyddanmark.dk) and the Department of Rheumatology, Frederiksberg Hospital (www.frederiksberghospital. dk). MoBa Genetics has been funded by the Research Council of Norway (#229624, #223273), South East and Western Norway Health Authorities, ERC AdG project SELECTionPREDISPOSED, Stiftelsen Kristian Gerhard Jebsen, Trond Mohn Foundation, the Novo Nordisk Foundation and the University of Bergen. KB and SB acknowledge the Novo Nordisk Foundation (grant NNF14CC0001). Funding Information: competing financial interests as employees. OAA is a consultant to HealthLytix. The following coauthors report the following but unrelated to the current report: Karolinska Institutet, with JA as principal investigator, has entered into agreements with the following entities, mainly but not exclusively for safety monitoring of rheumatology immunomodulators: Abbvie, BMS, Eli Lilly, Janssen, MSD, Pfizer, Roche, ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 1085-1095 |
| اللغة: | English |
| تدمد: | 0003-4967 |
| العلاقة: | Default journal; 81(8); http://www.scopus.com/inward/record.url?eid=2-s2.0-85130778612&partnerID=MN8TOARSTest; http://www.scopus.com/inward/record.url?scp=85130778612&partnerID=8YFLogxKTest; Sævarsdóttir , S , Stefansdottir , L , Sulem , P , Thorleifsson , G , Ferkingstad , E , Rutsdottir , G , Glintborg , B , Westerlind , H , Gröndal , G M , Loft , I C , Sorensen , S B , Lie , B A , Brink , M , Arlestig , L , Arnthorsson , A O , Baecklund , E , Banasik , K , Bank , S , Bjorkman , L I , Ellingsen , T , Erikstrup , C , Frei , O , Gjertsson , I , Gudbjartsson , D F , Gudjonsson , S A , Halldorsson , G H , Hendricks , O , Hillert , J , Hogdall , E , Jacobsen , S , Jensen , D V , Jonsson , H , Kastbom , A , Kockum , I , Kristensen , S , Kristjansdottir , H , Larsen , M H , Linauskas , A , Hauge , E-M , Loft , A G , Lúðvíksson , B R , Lund , S H , Markusson , Þ , Masson , G , Melsted , P , Moore , K H S , Munk , H , Nielsen , K R , Norddahl , G L , Oddsson , A , Olafsdottir , T A , Olason , P I , Olsson , T , Ostrowski , S R , Hørslev-Petersen , K , Rognvaldsson , S , Sanner , H , Silberberg , G N , Stefansson , H , Sørensen , E , Sørensen , I J , Turesson , C , Bergman , T , Alfredsson , L , Kvien , T K , Brunak , S , Steinsson , K , Andersen , V , Andreassen , O A , Rantapää-Dahlqvist , S , Hetland , M L , Klareskog , L , Askling , J , Padyukov , L , Pedersen , O B V , Thorsteinsdottir , U , Jonsdottir , I & Stefánsson , K 2022 , ' Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset ' , Default journal , vol. 81 , no. 8 , pp. 1085-1095 . https://doi.org/10.1136/annrheumdis-2021-221754Test; 9b60aa11-85a4-4bf8-ae8a-98ccbae07669; ORCID: /0000-0002-3806-2296/work/123415657; 85130778612; unpaywall: 10.1136/annrheumdis-2021-221754; https://hdl.handle.net/20.500.11815/3884Test |
| DOI: | 10.1136/annrheumdis-2021-221754 |
| الإتاحة: | https://doi.org/20.500.11815/3884Test https://doi.org/10.1136/annrheumdis-2021-221754Test https://hdl.handle.net/20.500.11815/3884Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.2FB1D6BF |
| قاعدة البيانات: | BASE |
| تدمد: | 00034967 |
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| DOI: | 10.1136/annrheumdis-2021-221754 |