دورية أكاديمية
Gastric Emptying Impacts the Timing of Meal Glucose Peak in Subjects with Uncomplicated Type 1 Diabetes
| العنوان: | Gastric Emptying Impacts the Timing of Meal Glucose Peak in Subjects with Uncomplicated Type 1 Diabetes |
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| المؤلفون: | Lupoli, Roberta, Creanza, Annalisa, Griffo, Ettore, Nardone, Gerardo, Rocco, Alba, Bozzetto, Lutgarda, Annuzzi, Giovanni, Riccardi, Gabriele, Capaldo, Brunella |
| المساهمون: | Lupoli, Roberta, Creanza, Annalisa, Griffo, Ettore, Nardone, Gerardo, Rocco, Alba, Bozzetto, Lutgarda, Annuzzi, Giovanni, Riccardi, Gabriele, Capaldo, Brunella |
| سنة النشر: | 2018 |
| المجموعة: | IRIS Università degli Studi di Napoli Federico II |
| مصطلحات موضوعية: | Adult, Blood Glucose, Cross-Sectional Studie, Diabetes Mellitus, Type 1, Female, Gastric Emptying, Ghrelin, Glucagon-Like Peptide 1, Human, Insulin, Male, Meal, Postprandial Period, Surveys and Questionnaire, Young Adult, Endocrinology, Diabetes and Metabolism, Biochemistry, Clinical Biochemistry, Biochemistry (medical) |
| الوصف: | Context Diabetes mellitus is associated with gastrointestinal (GI) motility dysfunction, ranging from delayed to accelerated gastric emptying (GE). Objective To evaluate GE in patients with type 1 diabetes mellitus (T1DM) without chronic complications and to investigate its relation with postprandial glucose and GI hormone responses. Design Cross-sectional study. Setting/Participants Forty-two patients with T1DM free of chronic complications referred to Federico II University and 31 healthy controls similar for age, sex, and body mass index. Interventions/Main Outcome Measures GE was assessed by using the 13 C-octanoate breath test with a standardized solid meal. During the meal, plasma glucose, ghrelin, and glucagon-like peptide 1 (GLP-1) responses were assessed, and GI symptoms were evaluated by a specific questionnaire. Results Patients with T1DM showed a significantly slower GE half-emptying time (GE t 1/2) (113 ± 34 minutes) than did controls (89 ± 17 minutes; P < 0.001). Thirty-six percent of T1DM showed a delayed GE (t 1/2 > 120 minutes), whereas all controls showed a normal GE. When patients with T1DM were stratified according to GE t 1/2, postmeal glucose response was significantly different between those with delayed and those with normal GE (P = 0.013). In particular, patients with T1DM and delayed GE showed a significantly longer mean time to peak glucose than did patients with normal GE (P = 0.004). In addition, GE t 1/2 was an independent predictor of the time to peak glucose (β = 0.329; P = 0.025). GLP-1 and ghrelin responses to the test meal, as well as the prevalence of GI symptoms, were similar between patients with T1DM and controls and between patients with T1DM with normal GE and those with delayed GE. Conclusions Delayed GE time is associated with a longer time to peak glucose. GE evaluation could be useful for individualizing the timing of preprandial insulin bolus in patients with T1DM. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/WOS:000434881400023; volume:103; issue:6; firstpage:2269; lastpage:2276; numberofpages:8; journal:THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM; http://hdl.handle.net/11588/737357Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85048692668; http://jcem.endojournals.orgTest |
| DOI: | 10.1210/jc.2017-02811 |
| الإتاحة: | https://doi.org/10.1210/jc.2017-02811Test http://hdl.handle.net/11588/737357Test http://jcem.endojournals.orgTest |
| رقم الانضمام: | edsbas.2EAFC3FE |
| قاعدة البيانات: | BASE |
| DOI: | 10.1210/jc.2017-02811 |
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