دورية أكاديمية
Conceptual framework for defining disease modification in systemic lupus erythematosus:A call for formal criteria
| العنوان: | Conceptual framework for defining disease modification in systemic lupus erythematosus:A call for formal criteria |
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| المؤلفون: | van Vollenhoven, Ronald, Askanase, Anca D., Bomback, Andrew S., Bruce, Ian N., Carroll, Angela, Dall'Era, Maria, Daniels, Mark, Levy, Roger A., Schwarting, Andreas, Quasny, Holly A., Urowitz, Murray B., Zhao, Ming-Hui, Furie, Richard |
| المصدر: | van Vollenhoven , R , Askanase , A D , Bomback , A S , Bruce , I N , Carroll , A , Dall'Era , M , Daniels , M , Levy , R A , Schwarting , A , Quasny , H A , Urowitz , M B , Zhao , M-H & Furie , R 2021 , ' Conceptual framework for defining disease modification in systemic lupus erythematosus : A call for formal criteria ' , Lupus Science and Medicine , vol. 9 , no. 1 , e000634 . https://doi.org/10.1136/lupus-2021-000634Test |
| سنة النشر: | 2021 |
| الوصف: | Disease modification has become a well-established concept in several therapeutic areas; however, no widely accepted definition of disease modification exists for SLE. We reviewed established definitions of disease modification in other conditions and identified a meaningful effect on ‘disease manifestations’ (ie, signs, symptoms and patient-reported outcomes) and on ‘disease outcomes’ (eg, long-term remission or progression of damage) as the key principles of disease modification, indicating a positive effect on the natural course of the disease. Based on these findings and the treatment goals and outcome measures for SLE, including lupus nephritis, we suggest a definition of disease modification based on disease activity indices and organ damage outcomes, with the latter as a key anchor. A set of evaluation criteria is also suggested. Establishing a definition of disease modification in SLE will clarify which treatments can be considered disease modifying, provide an opportunity to harmonise future clinical trial outcomes and enable comparison between therapies, all of which could ultimately help to improve patient outcomes. This publication seeks to catalyse further discussion and provide a framework to develop an accepted definition of disease modification in SLE. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://research.vumc.nl/en/publications/0d81e645-f106-4941-8567-7dc052a4fd6dTest |
| DOI: | 10.1136/lupus-2021-000634 |
| الإتاحة: | https://doi.org/10.1136/lupus-2021-000634Test https://research.vumc.nl/en/publications/0d81e645-f106-4941-8567-7dc052a4fd6dTest https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85131264890&origin=inwardTest https://www.ncbi.nlm.nih.gov/pubmed/35346982Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.2E9DC427 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/lupus-2021-000634 |
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