دورية أكاديمية
Microbiota profiling reveals alteration of gut microbial neurotransmitters in a mouse model of autism-associated 16p11.2 microduplication
| العنوان: | Microbiota profiling reveals alteration of gut microbial neurotransmitters in a mouse model of autism-associated 16p11.2 microduplication |
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| المؤلفون: | Fu, Zhang, Yang, Xiuyan, Jiang, Youheng, Mao, Xinliang, Liu, Hualin, Yang, Yanming, Chen, Jia, Chen, Zhumei, Li, Huiliang, Zhang, Xue-Song, Mao, Xinjun, Li, Ningning, Wang, Dilong, Jiang, Jian |
| المصدر: | Frontiers in Microbiology , 15 , Article 1331130. (2024) |
| بيانات النشر: | Frontiers Media SA |
| سنة النشر: | 2024 |
| المجموعة: | University College London: UCL Discovery |
| مصطلحات موضوعية: | 16S rRNA, 16p11.2, ASD, gut microbiota, histamine, metabolomic, neurotransmitter |
| الوصف: | The gut-brain axis is evident in modulating neuropsychiatric diseases including autism spectrum disorder (ASD). Chromosomal 16p11.2 microduplication 16p11.2dp/+ is among the most prevalent genetic copy number variations (CNV) linked with ASD. However, the implications of gut microbiota status underlying the development of ASD-like impairments induced by 16p11.2dp/+ remains unclear. To address this, we initially investigated a mouse model of 16p11.2dp/+, which exhibits social novelty deficit and repetitive behavior characteristic of ASD. Subsequently, we conducted a comparative analysis of the gut microbial community and metabolomic profiles between 16p11.2dp/+ and their wild-type counterparts using 16S rRNA sequencing and liquid chromatography-mass spectrometry (LC/MS). Our microbiota analysis revealed structural dysbiosis in 16p11.2dp/+ mice, characterized by reduced biodiversity and alterations in species abundance, as indicated by α/β-diversity analysis. Specifically, we observed reduced relative abundances of Faecalibaculum and Romboutsia, accompanied by an increase in Turicibacter and Prevotellaceae UCG_001 in 16p11.2dp/+ group. Metabolomic analysis identified 19 significantly altered metabolites and unveiled enriched amino acid metabolism pathways. Notably, a disruption in the predominantly histamine-centered neurotransmitter network was observed in 16p11.2dp/+ mice. Collectively, our findings delineate potential alterations and correlations among the gut microbiota and microbial neurotransmitters in 16p11.2dp/+ mice, providing new insights into the pathogenesis of and treatment for 16p11.2 CNV-associated ASD. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://discovery.ucl.ac.uk/id/eprint/10190633/1/fmicb-15-1331130.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10190633Test/ |
| الإتاحة: | https://discovery.ucl.ac.uk/id/eprint/10190633/1/fmicb-15-1331130.pdfTest https://discovery.ucl.ac.uk/id/eprint/10190633Test/ |
| حقوق: | open |
| رقم الانضمام: | edsbas.2E3878B4 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |